Catalog No.
YHD58702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser342-Leu588
Predicted molecular weight
29.24 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23508
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Colorectal mutant cancer protein, Protein MCC, MCC
Note
For research use only.
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers., PMID:1848370
Colon cancer. Consider the coiled coil..., PMID:1645848
Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene., PMID:1347524
Detection of multiallele polymorphisms within gene sequences by GC-clamped denaturing gradient gel electrophoresis., PMID:1539594
MaeIII polymorphism in sequence encoding 3' untranslated region of the MCC gene., PMID:1347926
[Characterization of the MCC gene product]., PMID:8920660
MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase., PMID:8626604
Somatic mutations of the APC gene in sporadic hepatoblastomas., PMID:8764128
Genetic evidence for the multicentric origin of synchronous multiple gastric carcinoma., PMID:9121123
Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas., PMID:9070658
A 33 bp minisatellite repeat upstream of the 'mutated in colon cancer' gene at chromosome 5q21., PMID:9694282
Antigen-pulsed CD8alpha+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node., PMID:9927521
Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma., PMID:10381126
Localization of MCC (mutated in colorectal cancer) in various tissues of mice and its involvement in cell differentiation., PMID:10449536
Three submicroscopic deletions at the APC locus and their rapid detection by quantitative-PCR analysis., PMID:10482959
Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75., PMID:11311560
[Identification of a novel MCC-homologue, MCC2, which interacts with PDZ-domain protein AIE-75]., PMID:11766388
[Genotyping of multiple genetic alterations of intrahepatic cholangiocarcinoma]., PMID:11798885
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway., PMID:14743216
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription., PMID:18591935
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells., PMID:19555689
Furrow-like invaginations of the yeast plasma membrane correspond to membrane compartment of Can1., PMID:19638406
C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane., PMID:20581291
Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population., PMID:21279955
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit., PMID:22100920
Mutated in colorectal cancer protein modulates the NFκB pathway., PMID:22213290
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells., PMID:22480440
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma., PMID:23540693
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer., PMID:23913442
MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm., PMID:24824780
[Follow up and gene mutation analysis in cases suspected as 3-methylcrotonyl-coenzyme A carboxylase deficiency by neonatal screening]., PMID:25190158
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas., PMID:25597018
Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform., PMID:25997006
Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance., PMID:27208794
Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia., PMID:27226254
[A novel compound heterozygous mutation causing 3-methylcrotonyl-CoA carboxylase deficiency]., PMID:27577216
Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4., PMID:28638476
'MCC' protein interacts with E-cadherin and β-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells., PMID:29035389
The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1., PMID:29144123
Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children., PMID:29695640
Viscosity changes and gel formation during storage of liquid micellar casein concentrates., PMID:34531054
MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation., PMID:36217793
Two germline mutations can serve as genetic susceptibility screening makers for a lung adenocarcinoma family., PMID:36781503
Effect of temperature and protein concentration on the protein types within the ultracentrifugation supernatant of liquid micellar casein concentrate., PMID:37641294
For research use only. Not for human or drug use.
