Catalog No.
YHB84701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr11-Lys94
Predicted molecular weight
37.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P00167
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytochrome b5, Microsomal cytochrome b5 type A, MCB5, CYB5A, CYB5
Note
For research use only.
CYB5A and autophagy-mediated cell death in pancreatic cancer., PMID:24448000
3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging., PMID:24832628
Protein interactomics based on direct molecular fishing on paramagnetic particles: practical realization and further SPR validation., PMID:25044858
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women., PMID:25225034
Differential expression of CYB5A in Chinese and European pig breeds due to genetic variations in the promoter region., PMID:25516134
Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy., PMID:25521918
CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women., PMID:25890314
Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma., PMID:26408419
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic., PMID:26862015
Combined steroidogenic characters of fetal adrenal and Leydig cells in childhood adrenocortical carcinoma., PMID:26940356
2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity., PMID:27136898
Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate., PMID:27623070
Thermodynamics of interactions between mammalian cytochromes P450 and b5., PMID:28238672
[The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450]., PMID:28414290
Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System., PMID:28671819
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1., PMID:28684414
Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction., PMID:28905435
[The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins]., PMID:29080871
SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates., PMID:30468857
Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue., PMID:30476104
11-Oxygenated C19 Steroids Do Not Decline With Age in Women., PMID:30753518
Label-Free LC-MS/MS Proteomics Analyses Reveal Proteomic Changes Accompanying MSTN KO in C2C12 Cells., PMID:31073529
Crystal structures of the naturally fused CS and cytochrome b5 reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+ nicotinamide ring., PMID:31282472
Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone., PMID:31509771
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein., PMID:32356894
The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent., PMID:33524149
Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation., PMID:33603407
Isolated 17, 20 Lyase Deficiency Secondary to a Novel CYB5A Variant: Comparison of Steroid Metabolomic Findings with Published Cases Provides Diagnostic Guidelines and Greater Insight into Its Biological Role., PMID:33626548
Successful Delivery in 17,20-Lyase Deficiency., PMID:33824988
Lack of association between CYB5A gene rs1790834 polymorphism and the response to leflunomide in women with rheumatoid arthritis., PMID:34160668
Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia., PMID:34616364
Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity., PMID:35043601
Redox-Regulation of α-Globin in Vascular Physiology., PMID:35052663
Identification and validation of a cigarette smoke-related five-gene signature as a prognostic biomarker in kidney renal clear cell carcinoma., PMID:35140327
An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse., PMID:35436854
Cytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib., PMID:35851063
Regulating Effect of Cytochrome b5 Overexpression on Human Breast Cancer Cells., PMID:35889429
Comparative proteomics reveals genetic mechanisms of body weight in Hu sheep and Dorper sheep., PMID:35995385
The association between CYB5A gene rs1790834 polymorphism and clinical improvement after 6 months of leflunomide treatment in women with rheumatoid arthritis., PMID:37289314
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time., PMID:37468957
Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism., PMID:37543511
Prioritising genetic findings for drug target identification and validation., PMID:38325120
The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis., PMID:38396748
From bioinformatics to clinical applications: a novel prognostic model of cuproptosis-related genes based on single-cell RNA sequencing data in hepatocellular carcinoma., PMID:39251909
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols., PMID:39489939
OXPHOS mediators in acute myeloid leukemia patients: Prognostic biomarkers and therapeutic targets for personalized medicine., PMID:39533394
Genetic insights into visceral obesity with health conditions, from disease susceptibility to therapeutic intervention., PMID:39835424
Two families, two pathways: a case series of 46, XY DSD with 17α-hydroxylase deficiency and isolated 17,20-lyase deficiency due to novel CYB5A variant., PMID:40123165
CYB5A promotes osteogenic differentiation of MC3T3-E1 cells through autophagy mediated by the AKT/mTOR/ULK1 signaling pathway., PMID:40246926
Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer., PMID:40253525
For research use only. Not for human or drug use.
