Catalog No.
YHE01901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln39-Pro193
Predicted molecular weight
19.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32970
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7
Hepatic transcriptome profiling unveils candidate genes in cattle with liver abscesses under the influence of beef genetics in dairy cattle., PMID:40489480
CD70 CAR-T cells empowered by TS-2021 through ex vivo transduction show potent antitumor efficacy against glioblastoma., PMID:40474210
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study., PMID:40404633
CD70-Targeted [18F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study., PMID:40306966
Regulation mechanism of chemokine CXCL3 in nasopharyngeal carcinoma., PMID:40239601
CD70 recruitment to the immunological synapse is dependent on CD20 in B cells., PMID:40232798
Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus., PMID:40220672
Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer., PMID:40205178
Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling., PMID:40165944
Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanoma., PMID:40148586
Comprehensive pan-cancer analysis reveals CD70 as a promising therapeutic target and biomarker in clear cell renal cell carcinoma., PMID:40113005
Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4-related ophthalmic disease., PMID:40078987
CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity., PMID:40046047
The DHH-DHHA1 domain phosphodiesterase of Mycoplasma bovis employs multiple strategies to modulate macrophage cellular processes., PMID:40023422
Development and Preclinical Evaluation of [64Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics., PMID:40015924
A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells., PMID:39906740
Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes., PMID:39867912
CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells., PMID:39793572
Direct Inhibitory Effect of HTLV-1-Infected T Cells on the Production of Anti-Ro/SS-A Antibody by B Cells from Patients with Sjögren's Syndrome., PMID:39775490
A mechanistic, functional, and clinical perspective on targeting CD70 in cancer., PMID:39725151
Diagnostic and predictive values of m5C‑associated genes in idiopathic pulmonary fibrosis., PMID:39704195
Safety and activity of CTX130, a CD70-targeted allogeneic CRISPR-Cas9-engineered CAR T-cell therapy, in patients with relapsed or refractory T-cell malignancies (COBALT-LYM): a single-arm, open-label, phase 1, dose-escalation study., PMID:39617017
CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML., PMID:39571145
CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond., PMID:39570653
IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy., PMID:39536753
CD70-Targeted Immuno-PET/CT Imaging of Clear Cell Renal Cell Carcinoma: A Translational Study., PMID:39510586
The future of cellular therapy for the treatment of renal cell carcinoma., PMID:39485013
Significance of CD70, VEGF, and CD90 Immunohistochemical Expression in Colorectal Cancer., PMID:39471037
CD70 is a potential prognostic marker and significantly regulates cellular function in diffuse large B-cell lymphoma., PMID:39446784
Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset., PMID:39432735
Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses., PMID:39420925
Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC., PMID:39411143
Integrated multi-omics profiling reveals the ZZZ3/CD70 axis is a super-enhancer-driven regulator of diffuse large B-cell lymphoma cell-natural killer cell interactions., PMID:39376717
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia., PMID:39285441
Pediatric Plasmablastic Lymphoma in the Setting of CD70 Deficiency., PMID:39262383
The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma., PMID:39227950
Development of bioassay platforms for biopharmaceuticals using Jurkat-CAR cells by AICD., PMID:39197208
Cadmium causes cerebral mitochondrial dysfunction through regulating mitochondrial HSF1., PMID:39127336
'Living drugs' target CD70 in advanced renal tumors., PMID:39079777
Noninvasive prediction of CCL2 expression level in high-grade glioma patients., PMID:39030882
CD70 identifies alloreactive T cells and represents a potential target for prevention and treatment of acute GVHD., PMID:39028952
CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis., PMID:38900051
Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion., PMID:38874582
Re: CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma., PMID:38735819
Expression of Potential Antibody-Drug Conjugate Targets in Cervical Cancer., PMID:38730739
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells., PMID:38683145
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment., PMID:38637886
Single-cell sequencing analysis and multiple machine-learning models revealed the cellular crosstalk of dendritic cells and identified FABP5 and KLRB1 as novel biomarkers for psoriasis., PMID:38596682
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma., PMID:38583184
CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy., PMID:38564778
For research use only. Not for human or drug use.
