Catalog No.
YHE01501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr128-Arg326
Predicted molecular weight
24.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32927
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytokine receptor common subunit beta, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD131, CSF2RB, IL3RB, IL5RB
CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting., PMID:39298477
Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent., PMID:38860546
Mechanistic Approach for Protective Effect of ARA290, a Specific Ligand for the Erythropoietin/CD131 Heteroreceptor, against Cisplatin-Induced Nephrotoxicity, the Involvement of Apoptosis and Inflammation Pathways., PMID:36085231
[A first-in-human clinical trial of piggyBac transposon-mediated GMR CAR-T cells against CD116-positive acute myeloid leukemia and juvenile myelomonocytic leukemia]., PMID:35922947
The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice., PMID:35008482
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4., PMID:34785669
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML., PMID:34750506
Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer., PMID:34729943
Rational engineering of an erythropoietin fusion protein to treat hypoxia., PMID:34725710
Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine., PMID:34440909
Carbamylated Erythropoietin Alleviates Kidney Damage in Diabetic Rats by Suppressing Oxidative Stress., PMID:34129202
The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor β- Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns., PMID:33784678
Genetic variants of small airways and interstitial pulmonary disease in children., PMID:33526882
Survival genes expression analysis following ionizing radiation to LiCl treated KG1a cells., PMID:31985347
Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections., PMID:31591168
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome., PMID:31303423
IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival., PMID:30742053
Evidence for an association of interferon gene variants with sudden infant death syndrome., PMID:30617847
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease., PMID:30124884
Activation of the β-common receptor by erythropoietin impairs acetylcholine-mediated vasodilation in mouse mesenteric arterioles., PMID:29939494
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide., PMID:29635062
Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients., PMID:29516317
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis., PMID:29026145
Characterisation of the porcine cytokines which activate the CD131βc common sub-unit, for potential immune-augmentation., PMID:28807497
Role of the β Common (βc) Family of Cytokines in Health and Disease., PMID:28716883
Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival., PMID:28302753
Could mucin 16 and colony-stimulating factor 2-receptor beta possible graft versus host disease biomarkers? Medical hypotheses., PMID:28236856
Lipid-Free Apolipoprotein A-I Reduces Progression of Atherosclerosis by Mobilizing Microdomain Cholesterol and Attenuating the Number of CD131 Expressing Cells: Monitoring Cholesterol Homeostasis Using the Cellular Ester to Total Cholesterol Ratio., PMID:27821400
Carbamylated Erythropoietin Outperforms Erythropoietin in the Treatment of AKI-on-CKD and Other AKI Models., PMID:26984884
Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons., PMID:27541284
Paradoxical effects of Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates on hCD45(+) cells in the bone marrow and spleen of leukemia-engrafted NOD/SCID or NRG mice., PMID:27497632
A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF., PMID:27377463
Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families., PMID:27373512
ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability., PMID:27172159
Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia., PMID:27118405
Auger electron-emitting (111)In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute myeloid leukemia (AML) cells displaying the CD123(+)/CD131(-) phenotype of leukemia stem cells., PMID:26748017
[Expression of CD131 Gene in Acute Myeloid Leukemic Cells]., PMID:26708867
CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors., PMID:26651396
Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor., PMID:26018904
Agonists of the tissue-protective erythropoietin receptor in the treatment of Parkinson's disease., PMID:25832721
Engineering superactive granulocyte macrophage colony-stimulating factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative disease., PMID:25737095
Carbamylated erythropoietin mediates retinal neuroprotection in streptozotocin-induced early-stage diabetic rats., PMID:25725621
The lack of CD131 and the inhibition of Neuro-2a growth by carbamylated erythropoietin., PMID:25656842
Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells., PMID:25373867
MicroSPECT/CT imaging of primary human AML engrafted into the bone marrow and spleen of NOD/SCID mice using 111In-DTPA-NLS-CSL360 radioimmunoconjugates recognizing the CD123+ / CD131- epitope expressed by leukemia stem cells., PMID:25278187
Immunosuppressive effects of erythropoietin on human alloreactive T cells., PMID:24676641
The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates., PMID:24637100
Potential role of erythropoietin receptors and ligands in attenuating apoptosis and inflammation in critical limb ischemia., PMID:24055514
The osteogenic effect of erythropoietin on human mesenchymal stromal cells is dose-dependent and involves non-hematopoietic receptors and multiple intracellular signaling pathways., PMID:24052411
Ketamine does not produce relief of neuropathic pain in mice lacking the β-common receptor (CD131)., PMID:23936499
For research use only. Not for human or drug use.
