Catalog No.
YHD56003
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser300-Tyr470
Predicted molecular weight
20.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23229
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD49f, Integrin alpha-6 heavy chain, Integrin alpha-6 light chain, Processed integrin alpha-6, Alpha6p, ITGA6
Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence., PMID:40463241
Establishment of salivary tissue-organoid biorepository: characterizing salivary gland stem/progenitor cells and novel differentiation marker PSMA/FOLH1., PMID:40399315
Self-Assembled Peptide PROTAC Prodrugs Targeting FOXM1 for Cancer Therapy., PMID:40367368
Hematopoietic stem cells in human fetal liver selectively express CD49f., PMID:40311859
An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment., PMID:40307853
The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior., PMID:40221767
SNRPB-mediated regulation of DDX39A splicing promotes ovarian cancer progression by regulating α6 integrin subunit expression., PMID:40216968
Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder., PMID:40207309
HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells., PMID:40198125
DNA methyltransferase 1/miR-342-3p/Forkhead box M1 signaling axis promotes self-renewal in cervical cancer stem-like cells in vitro and nude mice models., PMID:40160685
Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma., PMID:40083708
PD-L1+ CD49f+ CD133+ Circulating tumor cells predict outcome of patients with vulvar or cervical cancer after radio- and chemoradiotherapy., PMID:40083005
DNA Ligase 4 Inhibition Sensitizes Prostate Cancer to Immune Checkpoint Blockade In Vivo., PMID:40037856
Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways., PMID:39981899
Methodologic considerations on how to identify human hematopoietic stem cells., PMID:39892848
PEGylated Granulocyte Colony-Stimulating Factor and Plerixafor Enhance Autologous Stem and Progenitor Cell Mobilization and Transplantation in Pediatric Patients., PMID:39817857
Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer., PMID:39792419
Gingival keratinocyte adhesion on atomic layer-deposited hydroxyapatite coated titanium., PMID:39773092
Characterisation and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel., PMID:39725808
USP33 is an integrin α6 deubiquitinase and promotes esophageal squamous cell carcinoma cell migration and metastasis., PMID:39589547
Case Report: Alpha6 Integrin Disorder Presenting in Childhood with Nail Dysplasia and Onycholysis But No History of Fragile or Bullous Skin Changes., PMID:39583125
NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid., PMID:39516821
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy., PMID:39515328
A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing., PMID:39494910
FUT3 promotes gastric cancer cell migration by synthesizing Lea on ITGA6 and GLG1, affecting adhesion and vesicle distribution., PMID:39477144
Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitro., PMID:39449805
Development and preclinical evaluation of a cyclic PET tracer targeting integrin-α6 on colorectal cancer models., PMID:39447346
ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo., PMID:39436373
Investigating SNHG3 as a potential therapeutic approach for HCC stem cells., PMID:39427830
CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL., PMID:39420220
Circ_0038718 augments colorectal cancer progression through mediating the miR-761/miR-214-3p/ITGA6 axis., PMID:39405804
The Role of MicroRNA-124-3p in Breast Cancer Stem Cell Inhibition by Benzyl Isothiocyanate., PMID:39375243
Integrin α6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151., PMID:39329462
Casticin suppresses self-renewal related stemness via miR-342-3p-mediated FoxM1 downregulation in cervical cancer cells., PMID:39277988
The significance of CD49f expression in pediatric B-cell acute lymphoblastic leukemia., PMID:39259664
Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK., PMID:39059397
The potential role of collagen type VII in breast cancer proliferation., PMID:39030607
Netrin-1 Is an Important Mediator in Microglia Migration., PMID:39000184
A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa., PMID:38992003
Ankrd1 inhibits the FAK/Rho-GTPase/F-actin pathway by downregulating ITGA6 transcriptional to regulate myoblast functions., PMID:38988048
Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis., PMID:38900896
Systematic proteomics analysis revealed different expression of laminin interaction proteins in breast cancer: lower in luminal subtype and higher in claudin-low subtype., PMID:38881926
Identification of a ferroptosis-related prognostic signature and validation of ITGA6-AS1 in enhancing cell proliferation, migration and invasion in glioma., PMID:38875999
Alpha-6 integrin deletion delays the formation of Brca1/p53-deficient basal-like breast tumors by restricting luminal progenitor cell expansion., PMID:38835038
Small extracellular vesicles (sEVs)-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing., PMID:38773978
HCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L., PMID:38687323
Long noncoding RNA SNHG3 interacts with microRNA-502-3p to mediate ITGA6 expression in liver hepatocellular carcinoma., PMID:38680094
Role of basal cells in nasal polyp epithelium in the pathophysiology of eosinophilic chronic rhinosinusitis (eCRS)., PMID:38670810
ZC3H13 promotes ITGA6 m6A modification for chronic obstructive pulmonary disease progression., PMID:38670474
Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer., PMID:38658801
For research use only. Not for human or drug use.
