Catalog No.
PHJ60001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RXFP1 (His260-Arg409).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
LGR7,Relaxin family peptide receptor 1,Relaxin receptor 1,Leucine-rich repeat-containing G-protein coupled receptor 7,RXFP1
Purification
Purified by antigen affinity column.
Accession
Q9HBX9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction., PMID:40037346
Engineering and Characterization of a Long-Half-Life Relaxin Receptor RXFP1 Agonist., PMID:39134056
Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First-in-Human, Randomized, Single-Blind, Placebo-Controlled Study., PMID:39056338
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology., PMID:38945278
Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights., PMID:37398174
C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro., PMID:37047812
Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action., PMID:36982837
Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1., PMID:34972106
Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer., PMID:33561012
Receptor-independent modulation of TGF-β-induced pro-fibrotic pathways by relaxin-2 in human primary tubular epithelial cells., PMID:30078103
Luteal and hypophyseal expression of the canine relaxin (RLN) system during pregnancy: Implications for luteotropic function., PMID:29364921
Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients., PMID:26542729
Detection of relaxin receptor in the dorsoradial ligament, synovium, and articular cartilage of the trapeziometacarpal joint., PMID:24797570
Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow., PMID:22744867
The molecular detection of relaxin and its receptor RXFP1 in reproductive tissue of Felis catus and Lynx pardinus during pregnancy., PMID:22187673
Effect of relaxin on human sperm functions., PMID:21903973
Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats., PMID:20686183
Detection of RXFP1 receptors in skin biopsies from children with congenital adrenal hyperplasia: a preliminary report., PMID:19897422
Relaxin's involvement in extracellular matrix homeostasis., PMID:19416214
Role of relaxin in human osteoclastogenesis., PMID:19416193
RXFP1 is expressed on the sperm acrosome, and relaxin stimulates the acrosomal reaction of human spermatozoa., PMID:19416186
Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract., PMID:19416172
Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin., PMID:17425335
Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates., PMID:14633277
For research use only. Not for human or drug use.
