Catalog No.
YHM00401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly22-Trp295
Predicted molecular weight
33.66 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13747
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MHC class I antigen E, HLA class I histocompatibility antigen, alpha chain E, HLA-E, HLA-6.2, sHLA-E, HLAE
Note
For research use only.
Eight Novel HLA Class I Alleles Identified in Unrelated Haematopoietic Cell Donors and Recipients., PMID:39465562
Unlocking the therapeutic potential of the NKG2A-HLA-E immune checkpoint pathway in T cells and NK cells for cancer immunotherapy., PMID:39486805
IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells., PMID:39557863
Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint., PMID:39561763
The Novel HLA-E Allele, HLA-E*01:151, Identified in a Chinese Individual., PMID:39564865
[Research progresses of Qa-1 restricted CD8+ regulatory T cells in the pathogenesis of infectious diseases]., PMID:39566528
Targeting TSPEAR-AS2 suppresses tumor growth and interferon signaling in esophageal cancer., PMID:39567604
Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen., PMID:39578466
NKG2C Sequence Polymorphism Modulates the Expansion of Adaptive NK Cells in Response to Human CMV., PMID:39581700
[Construction of a stable 4T1 cell line expressing UL19 by the PiggyBac transposon system]., PMID:39584339
Nutrient transporter pattern in CD56dim NK cells: CD16 (FcγRIIIA)-dependent modulation and association with memory NK cell functional profile., PMID:39606236
Association Between NK Cell Genetic Variants and the Development of Long COVID Associated- and Prepandemic Small Fiber Neuropathy., PMID:39610330
All-Atom Simulations Reveal the Effect of Membrane Composition on the Signaling of the NKG2A/CD94/HLA-E Immune Receptor Complex., PMID:39621690
Hypoimmunogenic HLA-E Single Chain Inhibits Alloreactive Immune Responses., PMID:39621955
Targeting HLA-E in Lung Cancer: The Therapeutic Potential of IRF5-Engineered M1-Macrophage-Derived Exosomes., PMID:39623605
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness., PMID:39652590
Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals., PMID:39664387
Entry into the lytic cycle exposes EBV-infected cells to NK cell killing via upregulation of the MICB ligand for NKG2D and activation of the CD56bright and NKG2A+KIR+CD56dim subsets., PMID:39676862
NK-cell cytotoxicity toward pluripotent stem cells and their neural progeny: impacts of activating and inhibitory receptors and KIR/HLA mismatch., PMID:39708357
Single-cell profiling aligns CD56bright and cytomegalovirus-induced adaptive natural killer cells to a naïve-memory relationship., PMID:39742279
HLA-E: Immune Receptor Functional Mechanisms Revealed by Structural Studies., PMID:39753525
A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG., PMID:39757706
HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection., PMID:39790998
The Association of HLA-E Ligand and NKG2 Receptor Variation With Relapse and Mortality After Haploidentical Related Donor Transplantation., PMID:39798802
Virus-free CRISPR knockin of a chimeric antigen receptor into KLRC1 generates potent GD2-specific natural killer cells., PMID:39815622
Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study., PMID:39845968
Natural Killer Cell Education in Women With Recurrent Pregnancy Loss., PMID:39853841
Influence of HLA-B Leader (-21M/T) Dimorphism With Bw4/Bw6 Epitopes on Graft Versus Host Disease After Allogenic Haematopoietic Stem Cell Transplantation in North Indians., PMID:39865489
Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study)., PMID:39867897
Neutralizing IL-15 Inhibits Tissue-Damaging Immune Response in Ex Vivo Cultured Untreated Celiac Intestinal Mucosa., PMID:39937025
CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors., PMID:39958331
Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties., PMID:39984653
Plasma proteins and herpes simplex virus infection: a proteome-wide Mendelian randomization study., PMID:39992613
Association between human leukocyte antigen E expression and outcomes in solid tumors: a systematic review and meta-analysis., PMID:40066089
Memory-like NK cell differentiation, inhibitory NKG2A blockade, and improved recognition via antibody or CAR engineering combine to enhance NK cell attack against multiple myeloma., PMID:40073259
Identification and biophysical characterization of Plasmodium peptide binding by common African HLAs., PMID:40074802
HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors., PMID:40085431
Soluble HLA-E and Gastroesophageal Reflux Disease: A Novel Association., PMID:40147426
Stratifying Multiple Sclerosis Susceptibility Risk: The Role of HLA-E*01 and Infectious Mononucleosis in a Population Cohort., PMID:40192262
Allele and Haplotype Frequencies of 17 HLA-Related Loci in Shenzhen Chinese Population by Next-Generation Sequencing., PMID:40193066
Targeting the HLA-E-NKG2A axis in combination with MS-275 enhances NK cell-based immunotherapy against DMG., PMID:40296045
Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia., PMID:40320412
Optimization of hypo-alloimmunogenic multispecific CAR-T and SARS-CoV-2-specific T cells for off-the-shelf adoptive cell therapy., PMID:40321414
Structural Basis of SARS-CoV-2 Nsp13-Derived Peptide-Mediated NK Cell Activation., PMID:40331402
Human Cytomegalovirus Antigen Presentation by HLA-G in Infected Cells., PMID:40347012
The Novel HLA-E*01:152 Allele Identified in African Populations Using Next-Generation Sequencing., PMID:40364544
A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma., PMID:40370819
The Novel HLA-E Allele, HLA-E*01:01:46, Identified in a Chinese Individual., PMID:40384027
The Impact of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen-E, Human Leukocyte Antigen-G Polymorphisms on Innate Immunity and COVID-19 Severity., PMID:40391199
Identification of cross-stage, cross-species malaria CD8+ T cell antigens., PMID:40502747
For research use only. Not for human or drug use.
