Catalog No.
EMD85402
Expression system
Yeast
Species
Mus musculus (Mouse)
Protein length
Met112-Leu260
Predicted molecular weight
26.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27548
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD40 ligand, CD40-L, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD154, CD40 ligand, membrane form, CD40 ligand, soluble form, sCD40L, Cd40lg, Cd40l, Tnfsf5
Activated CD4+ T cells upregulate PD-L1 expression on B cells through CD40/CD40L signaling and direct contact in systemic lupus erythematosus., PMID:40499670
CD154:CD11b blockade enhances CD8+ T cell differentiation during infection but not transplantation., PMID:40485581
In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination., PMID:40480654
Exploring the Causal Association Between 91 Circulating Inflammatory Proteins and Neurodegenerative Diseases: A Bidirectional Two-Sample Mendelian Randomization and Bioinformatics Analysis., PMID:40462656
CD8+ T cell-derived CD40L mediates noncanonical cytotoxicity in CD40-expressing cancer cells., PMID:40397730
Case Report: CD40LG Arg203Ile variant underlies atypical phenotype of X-linked hyper IgM syndrome., PMID:40391217
Platelets and MMP‑9 contribute to esophageal cancer invasion via CD40‑CD154 interactions., PMID:40376974
Evaluation of Plasma Soluble Cd40 Ligand Levels in Children with Familial Mediterranean Fever and Its Relationship with Carotid Intima-Media Thickness., PMID:40361895
Platelet-Derived Soluble CD40L and Its Impact on Immune Modulation and Anti-IL6R Antibody Treatment Outcome in Rheumatoid Arthritis., PMID:40358149
Case Report: Co-occurrence of tubulitis and SARS-CoV-2 specific T-cells in a kidney transplant recipient., PMID:40343198
Long Noncoding RNA H19 Regulates the Foam Cell Formation of Vascular Smooth Muscle Cells by Inhibiting microRNA-107 to Activate the CD40/CD40L Pathway., PMID:40340885
A novel CD40LG mutation causing X‑linked hyper-IgM syndrome., PMID:40330326
Genetic evidence from Mendelian randomization links CD40 levels to increased risk of estrogen receptor-positive breast cancer., PMID:40295650
LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity., PMID:40246582
Ex Vivo Overactivation of Lymphocyte Subsets in Fibrotic Hypersensitivity Pneumonitis Is Blunted by a Sphingosine-1-Phosphate Receptor Ligand., PMID:40243992
The T-cell response to SARS-CoV- 2 vaccination persists beyond six months in rheumatoid arthritis patients treated with rituximab., PMID:40241223
CD4+ T-cell help delivery to monocyte-derived dendritic cells promotes effector differentiation of helper and cytotoxic T cells., PMID:40239818
OMIP-113: Characterization of Cytokine Producing T Cells in Swine., PMID:40231482
Construction and evaluation of a 180-day readmission prediction model for chronic heart failure patients based on sCD40L., PMID:40228270
Recognition of different subsets of alloreactive T cells by activation-induced markers., PMID:40204006
Mathematical modeling unveils the timeline of CAR-T cell therapy and macrophage-mediated cytokine release syndrome., PMID:40203243
CD40L stimulates tumor-infiltrating B-cells and improves ex vivo TIL expansion., PMID:40199608
CAR Treg synergy with anti-CD154 promotes infectious tolerance and dictates allogeneic heart transplant acceptance., PMID:40197364
Enhancing antitumor immunity through chemotherapeutic-derived lipid nanoparticle-induced immunogenic cell death and CD40L/Flt3L mRNA-mediated dendritic cell activation., PMID:40185331
sCD40 and sCD40L as candidate biomarkers of rheumatic diseases: a systematic review and meta-analysis with meta-regression., PMID:40176806
Temporal immune profiling in the cerebrospinal fluid and blood of patients with aneurysmal subarachnoid hemorrhage., PMID:40154495
Targeted immunotherapies for Graves' thyroidal & orbital diseases., PMID:40145088
Reduced Serum PD-L1 and Markers of Inflammation in Response to Alternate Day Fasting With a Low-Carbohydrate Intervention: A Secondary Analysis of a Single-Arm Trial., PMID:40145019
Effect of edaravone dexborneol combined with interventional thrombectomy on nerve function, cerebral hemodynamics, and serum levels of serum amyloid A, lipoprotein-associated phospholipase A2, and soluble CD40 ligand in elderly patients with ischemic stroke., PMID:40137846
Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs., PMID:40137720
Salvianolic Acid A From Salvia miltiorrhiza Suppresses Endometrial Carcinoma Progression via CD40-AKT-NF-κB Pathway., PMID:40134253
Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation., PMID:40122241
Diagnostic value of sTREM-1, sCD25, sCD40L and sCD130 in late-onset neonatal sepsis., PMID:40118381
Lupenone preserves T cell activity by recovery of CD40L expression and protection from cytotoxicity due to methamphetamine exposure., PMID:40111983
Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement., PMID:40090010
Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors., PMID:40089933
Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors., PMID:40074330
Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children., PMID:40062864
Transition from preclinical to clinical application of CTLA4-Ig co-stimulation blockage in beta-cell replacement therapy., PMID:40048867
Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules., PMID:40046411
Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications., PMID:40043936
Clustering Mycobacterium tuberculosis-specific CD154+CD4+ T cells for distinguishing tuberculosis disease from infection based on single-cell RNA-seq analysis., PMID:40010539
Administration of a Recombinant Fusion Protein of IFN-γ and CD154 Inhibited the Infection of Chicks with Salmonella enterica., PMID:40005871
Modified CD40L-Activated B-Cell Proliferation Model for Validating the Suppressive Activity of CD40-CD154 Pathway Inhibitors., PMID:39994946
Novel plasma biomarkers of amyloid plaque pathology and cortical thickness: Evaluation of the NULISA targeted proteomic platform in an ethnically diverse cohort., PMID:39989429
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice., PMID:39988202
Pro-inflammatory and anti-inflammatory immune biomarkers as predictors of neurodevelopment in young children exposed to HIV., PMID:39970188
CD40 induces PIR-A+ macrophages to promote chronic allograft rejection., PMID:39954660
Discrimination of Anti-Donor Response in Allogeneic Transplantation Using an Alloreactive T-Cell Detection Assay., PMID:39936124
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors., PMID:39924119
For research use only. Not for human or drug use.
