Catalog No.
PHE14301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human FUS (Ser282-Ser367).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:200, WB: 1:1000-1:4000 |
Target
RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS
Concentration
1.36 mg/ml
Purification
Purified by antigen affinity column.
Accession
P35637
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease., PMID:34112844
Focused ultrasound with anti-pGlu3 Aβ enhances efficacy in Alzheimer's disease-like mice via recruitment of peripheral immune cells., PMID:34186148
Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases., PMID:34803886
Rubella virus-associated uveitis: The essentiality of aqueous humor virological analysis., PMID:35285294
Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya., PMID:35390042
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3., PMID:35393905
Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice., PMID:35474517
Comparison of Sonication Patterns and Microbubble Administration Strategies for Focused Ultrasound-Mediated Large-Volume Drug Delivery., PMID:35476579
Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS., PMID:35581240
Gene Therapy in Amyotrophic Lateral Sclerosis., PMID:35805149
Acute Effects of Focused Ultrasound-Induced Blood-Brain Barrier Opening on Anti-Pyroglu3 Abeta Antibody Delivery and Immune Responses., PMID:35883506
Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases., PMID:36116720
An Immune Response to Heterologous ChAdOx1/BNT162b2 Vaccination against COVID-19: Evaluation of the anti-RBD Specific IgG Antibodies Titers and Interferon Gamma Release Assay (IGRA) Test Results., PMID:36146624
A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies., PMID:36276649
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation., PMID:36456471
Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: An 89Zr-cetuximab immunoPET study., PMID:36529256
Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model., PMID:36575534
Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions., PMID:36592411
Abl kinase-mediated FUS Tyr526 phosphorylation alters nucleocytoplasmic FUS localization in FTLD-FUS., PMID:37071594
The identification of high-performing antibodies for RNA-binding protein FUS for use in Western Blot, immunoprecipitation, and immunofluorescence., PMID:37384305
FUS-mediated blood-brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer's disease mice., PMID:37516718
Influence of focused ultrasound on locoregional drug delivery to the brain: Potential implications for brain tumor therapy., PMID:37659767
Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer's disease., PMID:37703663
Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation., PMID:37748140
Comparative Effectiveness of Tacrolimus and Infliximab in Hospitalized Patients With Ulcerative Colitis., PMID:37753937
Focused Ultrasound-Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model., PMID:37896238
Efficient PD-L1 imaging of murine glioblastoma with FUS-aided immunoPET by leveraging FcRn-antibody interaction., PMID:37908736
Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery., PMID:39897432
Gene of the month: DDIT3., PMID:38053287
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration., PMID:38111057
Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice., PMID:38235556
Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer., PMID:38266715
Remission Is Maintained after Switch from Dose-Optimised Intravenous Treatment to Subcutaneous Treatment with Vedolizumab in Inflammatory Bowel Disease., PMID:38399583
Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study., PMID:38419314
Fundamentals and Applications of Focused Ultrasound-Assisted Cancer Immune Checkpoint Inhibition for Solid Tumors., PMID:38543305
Myoepithelial tumors of soft tissue and bone in children and young adults: A clinicopathologic study of 40 cases occurring in patients ≤ 21 Years of age., PMID:38782103
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity., PMID:38869076
Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder., PMID:38961889
Safety, Efficacy and Clinical Applications of Focused Ultrasound-Mediated Blood Brain Barrier Opening in Alzheimer's Disease: A Systematic Review., PMID:39044508
A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery., PMID:39138578
Precision medicine focus on the central nervous system: Non-invasive therapeutic agent delivery with focused ultrasound and microbubbles., PMID:39306366
From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis., PMID:39334846
Sustained remission at long term follow-up in adolescents and young adults with chronic primary immune thrombocytopenia., PMID:39374586
Repetitive and extensive focused ultrasound-mediated bilateral frontal blood-brain barrier opening for Alzheimer's disease., PMID:39793012
Adeno-Associated Virus Self-Assembled with Tannic Acid and Phenylboronic Acid Polymers to Evade Neutralizing Antibodies and Reduce Adverse Events., PMID:39900524
Delivering Gd-Labeled IgG Antibodies Into the Mouse Brain Following Focused Ultrasound Treatment., PMID:40087107
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers., PMID:40291716
Drug delivery strategies to cross the blood-brain barrier in Alzheimer's disease: a comprehensive review on three promising strategies., PMID:40393907
Aducanumab delivery via focused ultrasound-induced transient blood-brain barrier opening in vivo., PMID:40404732
Ocular Hypertension or Glaucoma Risk Factor Prediction Models for Patients with Fuchs Uveitis Syndrome., PMID:40497633
For research use only. Not for human or drug use.
