Catalog No.
RHK92401
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Applications
ELISA, IF, IP
Target
ARID3A, DRIL1, DRIL3, DRX, E2FBP1, AT rich interactive domain 3A (BRIGHT-like), ARID domain-containing protein 3A, B-cell regulator of IgH transcription, Bright, Dead ringer-like protein 1, E2F-binding protein 1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99856
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA2127
Note
For research use only.
The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family., PMID:8543152
A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer., PMID:9780002
Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator., PMID:9858552
Regulation of matrix attachment region-dependent, lymphocyte-restricted transcription through differential localization within promyelocytic leukemia nuclear bodies., PMID:10921892
The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease., PMID:11120822
Differential regulation of immunoglobulin gene transcription via nuclear matrix-associated regions., PMID:11232275
Transcriptional activation by a matrix associating region-binding protein. contextual requirements for the function of bright., PMID:11294836
High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes., PMID:12193717
E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies., PMID:15017387
Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation., PMID:15456761
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright., PMID:15743806
A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes., PMID:16507996
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I., PMID:16738337
Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright., PMID:17312145
Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer., PMID:17386101
REKLES is an ARID3-restricted multifunctional domain., PMID:17400556
Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells., PMID:18981111
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright., PMID:19214191
The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development., PMID:21199920
The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production., PMID:21963220
Disease activity in systemic lupus erythematosus correlates with expression of the transcription factor AT-rich-interactive domain 3A., PMID:25185498
Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells., PMID:25535283
Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression., PMID:28580178
A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation., PMID:29114251
Control of B-1a cell development by instructive BCR signaling., PMID:29414528
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation., PMID:30930899
H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation., PMID:36532012
For research use only. Not for human or drug use.
