In Silico-Driven THIOMAB Approach for Stable PROTAC Conjugates by Docking Payloads in Antibody Cavities., PMID:40196986
Pulmonary NUT carcinoma, an elusive and refractory entity, shows transient response to chemotherapeutics and PD-1 inhibitor: a case report and literature review., PMID:40134436
New therapies in pulmonary arterial hypertension: Recent insights., PMID:39991439
PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti-PD-L1 Immunotherapy and Targeted Therapy., PMID:39978814
A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines., PMID:39935894
A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment., PMID:39816690
A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature., PMID:39727620
Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor., PMID:39681044
Chromatin remodelling drives immune cell-fibroblast communication in heart failure., PMID:39443808
A novel magnetic ligand-based assay for the electrochemical determination of BRD4., PMID:39032457
Welding PROxAb Shuttles: A Modular Approach for Generating Bispecific Antibodies via Site-Specific Protein-Protein Conjugation., PMID:38809610
Myoepithelial tumors of soft tissue and bone in children and young adults: A clinicopathologic study of 40 cases occurring in patients ≤ 21 Years of age., PMID:38782103
Exploring cytologic features and potential diagnostic challenges of metastatic NUT carcinoma to the parotid gland: A case report and a comprehensive literature review., PMID:38655736
BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL., PMID:38567724
A Functional Bayesian Model for Hydrogen-Deuterium Exchange Mass Spectrometry., PMID:37582225
Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumor immune evasion., PMID:37280393
Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor., PMID:37269669
BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5., PMID:37184294
Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners., PMID:37146018
On-demand integrated nano-engager converting cold tumors to hot via increased DNA damage and dual immune checkpoint inhibition., PMID:37139406
[Advances of structure and mechanisms of bromodomain-containing protein 4 and its related research in tumors]., PMID:36738206
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively., PMID:36711980
Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis., PMID:36711864
Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma., PMID:36708808
Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma., PMID:36696581
RNA Polymerase II "Pause" Prepares Promoters for Upcoming Transcription during Drosophila Development., PMID:36142573
NUT Carcinoma-An Underdiagnosed Malignancy., PMID:35957893
Injectable pH-responsive hydrogel for combinatorial chemoimmunotherapy tailored to the tumor microenvironment., PMID:35953828
BET inhibition triggers antitumor immunity by enhancing MHC class I expression in head and neck squamous cell carcinoma., PMID:35923111
Case report: NUT carcinoma in an elderly woman with unique morphology and immunophenotype highlights a diagnostic pitfall., PMID:35836519
A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia., PMID:35743155
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader., PMID:35649410
NUT carcinoma, an under-recognized malignancy: a clinicopathologic and molecular series of 6 cases showing a subset of patients with better prognosis and a rare ZNF532::NUTM1 fusion., PMID:35623465
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis., PMID:35215234
BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer., PMID:35083874
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer., PMID:35064087
BET Inhibition Enhances TNF-Mediated Antitumor Immunity., PMID:34782346
CPI-203 improves the efficacy of anti-PD-1 therapy by inhibiting the induced PD-L1 overexpression in liver cancer., PMID:34727389
BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall., PMID:34672128
Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer., PMID:34546978
Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic., PMID:34494353
BRD4 inhibition promotes TRAIL-induced apoptosis by suppressing the transcriptional activity of NF-κB in NSCLC., PMID:34400879
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes., PMID:34253616
Misleading Germ Cell Phenotype in Pulmonary NUT Carcinoma Harboring the ZNF532-NUTM1 Fusion., PMID:34232599
Thoracic NUT carcinoma: Common pathological features despite diversity of clinical presentations., PMID:34119933
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling., PMID:33907746
NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case., PMID:33891143
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy., PMID:33596073
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties., PMID:33596065
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma., PMID:33186461
For research use only. Not for human or drug use.
