Catalog No.
DHC33103
Expression system
Mammalian Cells
Species reactivity
Human
Isotype
Fusion - [human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) 2 - mFc]
Clonality
Monoclonal
Target
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P08476
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
RAP-011, RA -011, RAP011
Clone ID
RAP-011
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells., PMID:39667222
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling., PMID:39223366
INHBA(+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer., PMID:38360876
Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy., PMID:38079220
Prediction of anti-TNF therapy failure in ulcerative colitis patients by ensemble machine learning: A prospective study., PMID:37928018
Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas., PMID:36064338
Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma., PMID:35580932
Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice., PMID:33563697
Effect of CTCs and INHBA level on the effect and prognosis of different treatment methods for patients with early breast cancer., PMID:33378021
Activin A does not drive post-traumatic heterotopic ossification., PMID:32553795
IDO Targeting in Sarcoma: Biological and Clinical Implications., PMID:32194552
Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals., PMID:32133888
Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis., PMID:31613925
Activin A Signaling Regulates IL13Rα2 Expression to Promote Breast Cancer Metastasis., PMID:30805303
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages., PMID:27932444
Active immunization with GnRH-tandem-dimer peptide in young male rats reduces serum reproductive hormone concentrations, testicular development and spermatogenesis., PMID:26208395
Effects of activin A on survival, function and gene expression of pancreatic islets from non-diabetic and diabetic human donors., PMID:25833251
Nerve growth factor neutralization suppresses β-cell proliferation through activin A and betacellulin., PMID:25401376
Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models., PMID:25361680
Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile., PMID:25319955
Endogenous protection derived from activin A/Smads transduction loop stimulated via ischemic injury in PC12 cells., PMID:24141247
Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma., PMID:23321464
Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation., PMID:23293299
Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain., PMID:22296042
Immunolabeling of the inhibin-βA and -βB subunit in normal and malignant human cervical tissue and cervical cancer cell lines., PMID:21475087
Inhibin-betaA and -betaB subunits in normal and malignant glandular epithelium of uterine cervix and HeLa cervical cancer cell line., PMID:21082187
Value of serum and synovial fluid activin A and inhibin A in some rheumatic diseases., PMID:20704626
Inhibin-alpha, -betaA and -betaB subunits in uterine non-endometrioid carcinomas: prognostic significance and clinical implications., PMID:20599374
Role of activins and inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection., PMID:19692623
Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases., PMID:19231155
Synthesis, purification and bioactivity of recombinant human activin A expressed in the yeast Pichia pastoris., PMID:19027859
Activin A enhances MMP-7 activity via the transcription factor AP-1 in an esophageal squamous cell carcinoma cell line., PMID:18695873
A dual role of activin A in regulating immunoglobulin production of B cells., PMID:18353928
Activin subunit and receptor expression in normal and cleft human fetal palate tissues., PMID:18001154
Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma cells., PMID:17909904
Activating mutations in the luteinizing hormone receptor gene: a human model of non-follicle-stimulating hormone-dependent inhibin production and germ cell maturation., PMID:16684832
Inhibin/activin subunits beta-A (-betaA) and beta-B (-betaB) are differentially localised in normal, hyperplastic and malignant human endometrial tissue., PMID:16423381
Cyclic changes in messenger RNAs encoding inhibin/activin subunits in the ovary of the golden hamster (Mesocricetus auratus)., PMID:15930182
Inhibin/activin subunits (inhibin-alpha, -betaA and -betaB) are differentially expressed in human breast cancer and their metastasis., PMID:15583806
Inhibin/activin subunits alpha, beta-A and beta-B are differentially expressed in normal human endometrium throughout the menstrual cycle., PMID:15480736
Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis., PMID:12706302
Inhibin A is a follicle stimulating hormone-responsive marker of granulosa cell differentiation, which has both autocrine and paracrine actions in sheep., PMID:11312150
Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit., PMID:11134153
Activin, inhibin, and follistatin in zebrafish ovary: expression and role in oocyte maturation., PMID:10819759
Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors., PMID:10747314
Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle., PMID:9886535
Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia., PMID:9428386
Human activin betaA gene. Identification of novel 5' exon, functional promoter, and enhancers., PMID:8955111
Unique recognition of activin and inhibin by polyclonal antibodies to inhibin subunits., PMID:8797097
For research use only. Not for human or drug use.
