Catalog No.
DHE19601
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor, Tumor necrosis factor C receptor, Tumor necrosis factor receptor 2-related protein, Tumor necrosis factor receptor type III, TNF-RIII, TNFR-III, LTBR, D12S370, TNFCR, TNFR3, TNFRSF3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P36941
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
hCBE-11, CBE-11, HCBE 11, CBE11, CBE 11
Clone ID
CBE-11
Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung disease., PMID:39824903
LTβR Agonism Promotes Antitumor Immune Responses via Modulation of the Tumor Microenvironment., PMID:39137402
Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood., PMID:34335629
Amelioration of Murine Autoimmune Pancreatitis by Targeted LTβR Inhibition and Anti-CD20 Treatment., PMID:33154038
Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity., PMID:31862865
Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling., PMID:30069025
T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response., PMID:29743364
Novel mediators of statin effects on plaque in HIV: a proteomics approach., PMID:29369166
MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing., PMID:28733031
Hematopoietic LTβR deficiency results in skewed T cell cytokine profiles during a mucosal viral infection., PMID:26657790
Classical and alternative NF-κB signaling cooperate in regulating adipocyte differentiation and function., PMID:26403432
Mechanisms of human lymphotoxin beta receptor activation on upregulation of CCL5/RANTES production., PMID:26096887
Strategies to inhibit alloantibody production in alloprimed murine recipients of hematopoietic stem cell grafts., PMID:25762193
Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice., PMID:25740843
MicroRNA-100-5p indirectly modulates the expression of Il6, Ptgs1/2 and Tlr4 mRNA in the mouse follicular dendritic cell-like cell line, FL-Y., PMID:24944008
Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome., PMID:22044682
Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor., PMID:21071440
Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling., PMID:20139367
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction., PMID:18250437
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma., PMID:17692805
Isolated lymphoid follicle maturation induces the development of follicular dendritic cells., PMID:17163957
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy., PMID:17018619
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure., PMID:16934497
Parenteral nutrition impairs gut-associated lymphoid tissue and mucosal immunity by reducing lymphotoxin Beta receptor expression., PMID:16926565
Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3., PMID:16540654
Specific remodeling of splenic architecture by cytomegalovirus., PMID:16518465
Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes., PMID:15843551
Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine., PMID:15778401
Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin., PMID:15667567
Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes., PMID:15561941
The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis., PMID:15521015
Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity., PMID:15240662
Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium., PMID:15236187
Attenuation of graft arterial disease by manipulation of the LIGHT pathway., PMID:15178556
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy., PMID:15067315
Blocking lymphotoxin-beta receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis., PMID:15030510
Lymphotoxin pathway directs thymic Aire expression., PMID:14517552
Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells., PMID:12957791
Membrane lymphotoxin is required for resistance to Theiler's virus infection., PMID:12882833
A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis., PMID:12816989
A simple method for enriching populations of transfected CHO cells for cells of higher specific productivity., PMID:12799047
Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases., PMID:12794165
Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility., PMID:12768004
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death., PMID:12566458
Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo., PMID:12560241
Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway., PMID:12417575
The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function., PMID:12115617
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis., PMID:12077273
Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production., PMID:12006975
B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion., PMID:11994465
For research use only. Not for human or drug use.
