Catalog No.
YMD30401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Val31-Thr417
Predicted molecular weight
44.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q61790
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lymphocyte activation gene 3 protein, LAG-3, Activation-induced cytidine deaminase-linked autoimmunity protein, Aida, CD223, Secreted lymphocyte activation gene 3 protein, sLAG-3, Lag3
Peptide-based PET tracer targeting LAG-3 for evaluating the efficacy of immunotherapy in melanoma. [YMD30401]
A Novel Subset of Regulatory T Cells Induced by B Cells Alleviate the Severity of Immunological Diseases., PMID:39465485
Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein., PMID:38821932
CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24., PMID:38780647
Expression of lymphocyte activation gene-3 on CD4+T cells is regulated by cytokine interleukin-18 in myasthenia gravis., PMID:38325197
Clinical Significance of Soluble LAG-3 (sLAG-3) in Patients With Cervical Cancer Determined via Enzyme-Linked Immunosorbent Assay With Monoclonal Antibodies., PMID:37968933
LAG-3 transcriptomic expression patterns across malignancies: Implications for precision immunotherapeutics., PMID:37132280
Research progress of immune heckpoint LAG-3 in gastric cancer: a narrative review., PMID:36647874
Suppression of Streptococcosis and Modulation of the Gut Bacteriome in Nile Tilapia (Oreochromis niloticus) by the Marine Sediment Bacteria Bacillus haynesii and Advenella mimigardefordensis., PMID:36453920
Epitope Mapping of Therapeutic Antibodies Targeting Human LAG3., PMID:36104110
Clinical significance of LAG-3 on microvessel density in primary hepatocellular carcinoma., PMID:35900485
Lymphocyte activation gene-3 (LAG-3) regulatory T cells: An evolving biomarker for treatment response in autoimmune diseases., PMID:35341974
Lymphocyte-activating gene-3 expression is associated with tumor-infiltrating lymphocyte levels in HER2-positive breast cancers., PMID:34918659
Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19., PMID:34913354
Molecular and Clinical Characterization of LAG3 in Breast Cancer Through 2994 Samples., PMID:34267742
Global Screening of LUBAC and OTULIN Interacting Proteins by Human Proteome Microarray., PMID:34262903
[Progress on tumor immune checkpoints and their inhibitors in tumor therapy]., PMID:34140079
Research Progress Concerning Dual Blockade of Lymphocyte-Activation Gene 3 and Programmed Death-1/Programmed Death-1 Ligand-1 Blockade in Cancer Immunotherapy: Preclinical and Clinical Evidence of This Potentially More Effective Immunotherapy Strategy., PMID:33488573
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial., PMID:33184050
Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma., PMID:32861198
LAG3 (CD223) and autoimmunity: Emerging evidence., PMID:32576412
PD-L1 and LAG-3 expression in advanced cutaneous squamous cell carcinomas., PMID:32279340
LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma., PMID:32234847
Ectopic expression of LAG-3 in non-small-cell lung cancer cells and its clinical significance., PMID:32077528
[Next generation of anti-immune checkpoints antibodies]., PMID:31903901
Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor., PMID:31604537
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation., PMID:30792213
Symposium review: Immunological detection of the bovine conceptus during early pregnancy., PMID:30712941
Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression., PMID:30279468
Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer., PMID:30179225
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells., PMID:29553498
Co-inhibitory profile and cytotoxicity of CD57+ PD-1- T cells in end-stage renal disease patients., PMID:29027667
Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells., PMID:28434981
LAG3 (CD223) as a cancer immunotherapy target., PMID:28258692
NK1.1- CD4+ NKG2D+ T cells suppress DSS-induced colitis in mice through production of TGF-β., PMID:28224733
Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation., PMID:27821578
T-cell polarization: Potential serological markers in preterm and term infants., PMID:27416057
Characteristics of peripheral blood CD4+CD25+ regulatory T cells and related cytokines in severe atopic dermatitis., PMID:27184163
[Decreased expression levels of LAG-3 and CD49b on CD14+ cells in peripheral blood of patients with recurrent spontaneous abortion]., PMID:26927558
Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive., PMID:25974019
The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects., PMID:25780040
Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling., PMID:25108024
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors., PMID:24667641
Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection., PMID:24324159
Lymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral load., PMID:24180338
Prenatal cadmium exposure alters postnatal immune cell development and function., PMID:22521604
Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3., PMID:21873518
MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis., PMID:21441454
Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates., PMID:21352204
LAG-3 in Cancer Immunotherapy., PMID:21086108
Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4., PMID:20391435
For research use only. Not for human or drug use.
