Catalog No.
VXX17701
Species reactivity
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
Immunoglobulin A1 protease, IgA1 protease, 3.4.24.13, IgA-specific zinc metalloproteinase, iga, spr1042
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q59947
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
mAb2
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease., PMID:33247098
Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections., PMID:30797878
Pneumococcal IgA1 protease subverts specific protection by human IgA1., PMID:23820749
Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae., PMID:18088426
Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae., PMID:17261616
Development of lactococcal GEM-based pneumococcal vaccines., PMID:17081660
Sites in the CH3 domain of human IgA1 that influence sensitivity to bacterial IgA1 proteases., PMID:16951354
The influences of hinge length and composition on the susceptibility of human IgA to cleavage by diverse bacterial IgA1 proteases., PMID:15944283
Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases., PMID:15731049
Development of antibodies against pneumococcal proteins alpha-enolase, immunoglobulin A1 protease, streptococcal lipoprotein rotamase A, and putative proteinase maturation protein A in relation to pneumococcal carriage and Otitis Media., PMID:15246605
Antibody-dependent enhancement of infection: bacteria do it too., PMID:12967664
Antibody-enhanced pneumococcal adherence requires IgA1 protease., PMID:12642661
Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases., PMID:12595464
Antibody reactivity of a standardized human serum protein solution against a spectrum of microbial pathogens and toxins: comparison with fresh frozen plasma., PMID:11982956
Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases., PMID:10639405
Immunoglobulins in nasal secretions of healthy humans: structural integrity of secretory immunoglobulin A1 (IgA1) and occurrence of neutralizing antibodies to IgA1 proteases of nasal bacteria., PMID:10618273
Invasive isolates of Neisseria meningitidis possess enhanced immunoglobulin A1 protease activity compared to colonizing strains., PMID:9973321
IgA1 protease production by bacteria colonizing the upper respiratory tract., PMID:9561383
Comparative analysis of immunoglobulin A1 protease activity among bacteria representing different genera, species, and strains., PMID:9353019
Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence., PMID:8703438
Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a comparative study of ape serum IgAs as substrates., PMID:8641803
Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae., PMID:7591053
Antigenic relationships among immunoglobulin A1 proteases from Haemophilus, Neisseria, and Streptococcus species., PMID:8039886
Lack of cleavage of immunoglobulin A (IgA) from rhesus monkeys by bacterial IgA1 proteases., PMID:2037384
Production of immunoglobulin A protease by Streptococcus pneumoniae from animals., PMID:2117567
Resistance of normal serum IgA and secretory IgA to bacterial IgA proteases: evidence for the presence of enzyme-neutralizing antibodies in both serum and secretory IgA, and also in serum IgG., PMID:3127662
A hypothetical model for the development of invasive infection due to IgA1 protease-producing bacteria., PMID:3122532
A novel IgA protease from Clostridium sp. capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins., PMID:3880575
New method that uses binding of immunoglobulin A to group A streptococcal immunoglobulin A Fc receptors for demonstration of microbial immunoglobulin A protease activity., PMID:7016917
Specific proteolysis of human IgA by Streptococcus pneumoniae and Haemophilus influenzae., PMID:6989925
Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease., PMID:40878
For research use only. Not for human or drug use.
