Catalog No.
PHC97301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TDGF1/CRIPTO (Leu31-Thr172).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cripto-1 growth factor, Teratocarcinoma-derived growth factor 1, TDGF1, CRIPTO, Epidermal growth factor-like cripto protein CR1, CRGF
Purification
Purified by antigen affinity column.
Accession
P13385
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Uncovering potential targets for antibody-drug conjugates in the treatment of gynecologic malignancies., PMID:40046734
Cripto-1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains., PMID:39840816
Recombinant humanized Fab fragments targeting the CFC domain of human Cripto-1., PMID:38150919
GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases., PMID:35933036
A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth., PMID:33567764
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress., PMID:33187540
An evaluation of different Cripto-1 antibodies and their variable results., PMID:31310365
Development of conformational antibodies targeting Cripto-1 with neutralizing effects in vitro., PMID:30703478
Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers., PMID:30207211
Administration of Cripto in GRP78 overexpressed human MSCs enhances stem cell viability and angiogenesis during human MSC transplantation therapy., PMID:29722092
Cripto-1 promotes epithelial-mesenchymal transition in prostate cancer via Wnt/β-catenin signaling., PMID:28098905
New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding., PMID:26370966
Cripto-1: an extracellular protein - connecting the sequestered biological dots., PMID:26327334
Cripto-1 as a novel therapeutic target for triple negative breast cancer., PMID:26059540
An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours., PMID:21458984
Targeting the embryonic gene Cripto-1 in cancer and beyond., PMID:21073352
Cripto-1: an embryonic gene that promotes tumorigenesis., PMID:20624125
Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells., PMID:20549704
[Role of Cripto-1 protein in development and target therapy of breast cancer]., PMID:20388407
Human Cripto-1 as a target for a cancer vaccine: WO2008040759., PMID:19441915
Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways., PMID:19421146
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation., PMID:18772886
Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma., PMID:18604175
Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells., PMID:18202186
Cripto-1 expression in uveal melanoma: an immunohistochemical study., PMID:17412323
Rabbit embryonic stem cell lines derived from fertilized, parthenogenetic or somatic cell nuclear transfer embryos., PMID:16996056
Cripto monoclonal antibodies., PMID:16193101
Cripto as a target for cancer immunotherapy., PMID:15934922
Role of human cripto-1 in tumor angiogenesis., PMID:15657343
Cripto: a novel target for antibody-based cancer immunotherapy., PMID:15173016
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo., PMID:12925698
Decrypting the role of Cripto in tumorigenesis., PMID:12925690
A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src., PMID:12649175
Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein., PMID:11807813
Chick CFC controls Lefty1 expression in the embryonic midline and nodal expression in the lateral plate., PMID:11397007
Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers., PMID:10749108
Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells., PMID:10425310
Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor., PMID:10085099
EGF-related peptides are involved in the proliferation and survival of MDA-MB-468 human breast carcinoma cells., PMID:9935161
Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells., PMID:9648926
Cripto expression in human urological tumors., PMID:9022129
Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line., PMID:8635871
Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides., PMID:9816209
Identification and biological characterization of an epidermal growth factor-related protein: cripto-1., PMID:8006041
Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas., PMID:8180021
For research use only. Not for human or drug use.
