Catalog No.
PHC23801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD141/THBD (Ala19-Asp486).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
THBD, THRM, CD141, Thrombomodulin, Fetomodulin, TM
Purification
Purified by antigen affinity column.
Accession
P07204
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells., PMID:39694917
Targeting complement dysregulation: eculizumab in scleroderma renal crisis management-a case-based review., PMID:39147912
A randomized phase II clinical trial of stereotactic body radiation therapy (SBRT) and systemic pembrolizumab with or without intratumoral avelumab/ipilimumab plus CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells in solid tumors., PMID:38954010
Intratumoral administration of the immunologic adjuvant AS01B in combination with autologous CD1c (BDCA-1)+/CD141 (BDCA-3)+ myeloid dendritic cells plus ipilimumab and intravenous nivolumab in patients with refractory advanced melanoma., PMID:38212127
Skin-Grafting and Dendritic Cell "Boosted" Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines., PMID:37626903
PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer., PMID:36272973
Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations., PMID:34054804
Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model., PMID:33737342
Systemic inflammation is a determinant of outcomes of CD40 agonist-based therapy in pancreatic cancer patients., PMID:33497362
Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells., PMID:32737142
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells., PMID:32547743
Identification of unique clusters of T, dendritic, and innate lymphoid cells in the peritoneal fluid of ovarian cancer patients., PMID:32524661
Prophylactic Effect of Recombinant Human Soluble Thrombomodulin for Hepatic Sinusoidal Obstruction Syndrome Model Mice., PMID:32354890
Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells., PMID:32273347
Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis., PMID:31857644
Revisiting the activated protein C-protein S-thrombomodulin ternary pathway: Impact of new understanding on its laboratory investigation., PMID:31256946
Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses., PMID:31213473
Immune Cell Composition in Human Non-small Cell Lung Cancer., PMID:30774636
Novel Modified Vaccinia Virus Ankara Vector Expressing Anti-apoptotic Gene B13R Delays Apoptosis and Enhances Humoral Responses., PMID:30541829
Outcome of membranoproliferative glomerulonephritis and C3-glomerulopathy in children and adolescents., PMID:30238151
Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin., PMID:29895622
CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion., PMID:29755453
Increased factor VIII plays a significant role in plasma hypercoagulability phenotype of patients with cirrhosis., PMID:29577605
Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent Progress., PMID:29538262
The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells., PMID:29439742
Identification of a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells in Teleost Respiratory Surfaces., PMID:29422901
Biocompatible coupling of therapeutic fusion proteins to human erythrocytes., PMID:29365311
TAFRO Syndrome with Disseminated Intravascular Coagulation Successfully Treated with Tocilizumab and Recombinant Thrombomodulin., PMID:29279488
Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model., PMID:29246581
Anti-CENP-B and anti-TOPO-1-containing sera from systemic sclerosis-related diseases with Raynaud's phenomenon induce vascular endothelial cell senescence not via classical p53-p21 pathway., PMID:28940121
Sinusoidal obstructive syndrome prophylaxis with recombinant human soluble thrombomodulin is feasible in gemtuzumab ozogamicin-treated patients undergoing allogeneic hematopoietic cell transplantation., PMID:28368378
Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life., PMID:28329707
Effects of alloantibodies to human leukocyte antigen on endothelial expression and serum levels of thrombomodulin., PMID:28239987
Three-Dimensional Arrangement of Human Bone Marrow Microvessels Revealed by Immunohistology in Undecalcified Sections., PMID:27997569
Highly sensitive turn-on fluorescence detection of thrombomodulin based on fluorescence resonance energy transfer., PMID:27780127
Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system., PMID:27590316
Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats., PMID:27474498
Histones Induce the Procoagulant Phenotype of Endothelial Cells through Tissue Factor Up-Regulation and Thrombomodulin Down-Regulation., PMID:27258428
Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy., PMID:27179104
Purification of Human Dendritic Cell Subsets from Peripheral Blood., PMID:27142015
Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation., PMID:27077599
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft., PMID:27045379
Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome., PMID:26895476
Allergen-Specific Immunotherapy Alters the Frequency, as well as the FcR and CLR Expression Profiles of Human Dendritic Cell Subsets., PMID:26863539
Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease., PMID:26784676
Profiling of primary peripheral blood- and monocyte-derived dendritic cells using monoclonal antibodies from the HLDA10 Workshop in Wollongong, Australia., PMID:26682057
Expression analysis of surface molecules on human thymic dendritic cells with the 10th HLDA Workshop antibody panel., PMID:26682055
TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells., PMID:26673143
Activation of protein C and thrombin activable fibrinolysis inhibitor on cultured human endothelial cells., PMID:26663133
Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy., PMID:26522402
For research use only. Not for human or drug use.
