Anti-ACAN Polyclonal Antibody

Catalog No.

PHD15201

Species reactivity

Human,Mouse,Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ACAN (Glu2321-His2530).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Chondroitin sulfate proteoglycan 1, Cartilage-specific proteoglycan core protein, CSPG1, AGC1, CSPCP, ACAN, Aggrecan core protein, MSK16, Chondroitin sulfate proteoglycan core protein 1

Purification

Purified by antigen affinity column.

Accession

P16112

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Comparison of tendon healing using local platelet-rich plasma, erythropoietin, and erythropoietin-bevacizumab in a rat Achilles tenotomy model., PMID:40235417

Molecular signatures of Haemonchus contortus infection in sheep: A comparative serum proteomic study on susceptible and resistant sheep breeds., PMID:39116550

Syndecan-4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis., PMID:39101668

Combinatory Nanovesicle with siRNA-Loaded Extracellular Vesicle and IGF-1 for Osteoarthritis Treatments., PMID:38791285

Recombinant Human Proteoglycan Aggrecan-G1 Domain-induced Arthritis (GIA) Mouse Model., PMID:38752927

Posterior vitreous attachment as a risk factor for endophthalmitis following intravitreal antivascular endothelial growth factor injection., PMID:38748185

Role of NRF2 and reactive aldehydes in acute cellular rejection in liver transplant recipients., PMID:37742477

Biopolymer collagen-chitosan scaffold containing Aloe vera for chondrogenic efficacy on cartilage tissue engineering., PMID:37482169

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix., PMID:36937743

Individual immune cell and cytokine profiles determine platelet-rich plasma composition., PMID:36627721

Interleukin-6 neutralization and regulatory T cells are additive in chondroprotection from IL-1β-induced inflammation., PMID:36205183

Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture., PMID:35372643

Blockade of IL-33 signalling attenuates osteoarthritis., PMID:33133598

Ligustrazine Prevents Intervertebral Disc Degeneration via Suppression of Aberrant TGFβ Activation in Nucleus Pulposus Cells., PMID:31886227

[Prevalence and characteristics of serum autoantibodies in patients followed for infertility at Grenoble University Hospital]., PMID:31727487

Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies., PMID:31366218

Enhanced chondrogenesis from human embryonic stem cells., PMID:31326745

Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway., PMID:30926814

Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation., PMID:30872687

Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation., PMID:30600473

Heparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes., PMID:29803826

Hyaluronic acid promotes proliferation and migration of human meniscus cells via a CD44-dependent mechanism., PMID:29658360

Isolation and characterization of buffalo (bubalus bubalis) amniotic mesenchymal stem cells derived from amnion from the first trimester pregnancy., PMID:29515060

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection., PMID:29515038

No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA., PMID:28879048

The role of human natural killer-1 (HNK-1) carbohydrate in neuronal plasticity and disease., PMID:28709864

MicroRNA-494 promotes apoptosis and extracellular matrix degradation in degenerative human nucleus pulposus cells., PMID:28427186

MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation., PMID:27884646

Deficient glucose and glutamine metabolism in Aralar/AGC1/Slc25a12 knockout mice contributes to altered visual function., PMID:27746674

Molecular heterogeneity of aggrecan-based perineuronal nets around five subclasses of parvalbumin-expressing neurons in the mouse hippocampus., PMID:27718219

Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1β-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte., PMID:27555113

[Association between the expression of Aggrecan and the distribution of Aggrecan gene variable number of tandem repeats with symptomatic lumbar disc herniation]., PMID:25908284

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala., PMID:25603412

Demineralized bone matrix combined bone marrow mesenchymal stem cells, bone morphogenetic protein-2 and transforming growth factor-β3 gene promoted pig cartilage defect repair., PMID:25545777

Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes., PMID:25296561

Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model., PMID:25146000

Interleukin 6 mediates selected effects of Notch in chondrocytes., PMID:23954701

ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain., PMID:23897278

Bidirectional and mutually beneficial interactions between human mesenchymal stem cells and osteoarthritic chondrocytes in micromass co-cultures., PMID:23627821

Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration., PMID:22920724

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes., PMID:22812570

MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover., PMID:22670872

Zonal differences in meniscus matrix turnover and cytokine response., PMID:22062355

Expression of extracellular matrix proteins fibulin-1 and fibulin-2 by human corneal fibroblasts., PMID:17612964

Transforming growth factor-beta1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes., PMID:16344134

A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis., PMID:16257242

Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan., PMID:16232217

Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons., PMID:16112096

Genetic control of experimental spondylarthropathy., PMID:16059927

Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling., PMID:15743758

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