Catalog No.
PHD75001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DCK (Met1-Leu260).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
dCK, Deoxyguanosine kinase, Deoxycytidine kinase, Deoxyadenosine kinase, DCK
Purification
Purified by antigen affinity column.
Accession
P27707
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy., PMID:40500294
The Results of ADVANCE-CIDP IVIG Trial: Intravenous Immunoglobulin 10% Therapy With GAMMAGARD LIQUID/Kiovig for Treatment of Relapse in Chronic Inflammatory Demyelinating Polyradiculoneuropathy., PMID:40247653
Exploring autoantigens in autoimmune limbic encephalitis using phage immunoprecipitation sequencing., PMID:40133514
Bivalent RSVpreF Vaccine in Adults 18 to <60 Years Old With High-Risk Conditions., PMID:39523547
Respiratory Syncytial Virus Prefusion F Vaccination: Antibody Persistence and Revaccination., PMID:38606958
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease., PMID:38589621
A Bivalent Omicron-BA.4/BA.5-Adapted BNT162b2 Booster in ≥12-Year-Olds., PMID:38016021
Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice., PMID:37824334
CD98hc is a target for brain delivery of biotherapeutics., PMID:37598178
Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages., PMID:36630914
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells., PMID:36171284
COVID-19 rebound after Paxlovid treatment during Omicron BA.5 vs BA.2.12.1 subvariant predominance period., PMID:35982673
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection., PMID:35792746
Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine., PMID:35739094
BNT162b2-elicited neutralization of Delta plus, Lambda, Mu, B.1.1.519, and Theta SARS-CoV-2 variants., PMID:35396516
Neutralization and durability of 2 or 3 doses of the BNT162b2 vaccine against Omicron SARS-CoV-2., PMID:35245438
GnRH receptor-activating autoantibodies in polycystic ovary syndrome: identification of functional epitopes and development of epitope mimetic inhibitors., PMID:34807394
RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines., PMID:32820216
Modulating tumor immunity by metronomic dosing of oxaliplatin incorporated in multiple oral nanoemulsion., PMID:32169534
Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial., PMID:30302285
Examination of Hypoxanthine Guanine Phosphoribosyltransferase as a biomarker for colorectal cancer patients., PMID:30250925
Metuzumab enhanced chemosensitivity and apoptosis in non-small cell lung carcinoma., PMID:28055291
β1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits., PMID:26517045
A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit., PMID:26446828
AT2R autoantibodies block angiotensin II and AT1R autoantibody-induced vasoconstriction., PMID:26259590
Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit., PMID:25691619
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates., PMID:25026611
Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents., PMID:24972933
Prevalence of clinically significant red blood cell alloantibodies in pregnant women at a large tertiary-care facility., PMID:24689681
Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging., PMID:24654787
Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism., PMID:24552217
Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes., PMID:21970838
Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma., PMID:20811706
Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chloro-2'-deoxyadenosine (2-CdA) and Rituximab., PMID:19647871
TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus., PMID:19047436
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells., PMID:18313307
Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes., PMID:17350163
Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia., PMID:17146554
(+/-)-3'-O, 4'-O-dicynnamoyl-cis-khellactone, a derivative of (+/-)-praeruptorin A, reverses P-glycoprotein mediated multidrug resistance in cancer cells., PMID:16875827
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity., PMID:16361699
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours., PMID:15976334
Activation of deoxycytidine kinase in lymphocytes is calcium dependent and involves a conformational change detectable by native immunostaining., PMID:15104248
Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity., PMID:14514691
Purine metabolism in leukocytes and erythrocytes in Graves' or Hashimoto's disease., PMID:12489570
Role of deoxycytidine kinase (dCK) activity in gemcitabine's radioenhancement in mice and human cell lines in vitro., PMID:12142097
Molecular and biochemical mechanisms of fludarabine and cladribine resistance in a human promyelocytic cell line., PMID:10606241
The intracellular localization of deoxycytidine kinase., PMID:9804782
A synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein: isolation and immunochemical characterization., PMID:8939461
Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780., PMID:7481843
Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780., PMID:8033147