Catalog No.
PHJ22901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SIRT6 (Met1-Ser355).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SIR2-like protein 6,SIRT6,NAD-dependent protein deacetylase sirtuin-6,SIR2L6,Regulatory protein SIR2 homolog 6
Purification
Purified by antigen affinity column.
Accession
Q8N6T7
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice., PMID:39971710
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy., PMID:39754634
SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin., PMID:38986922
TSPAN8+ myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer., PMID:38569015
A bifunctional anti-PCSK9 scFv/Exendin-4 fusion protein exhibits enhanced lipid-lowering effects via targeting multiple signaling pathways in HFD-fed mice., PMID:37739280
Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7., PMID:37460032
Overexpression of SIRT6 alleviates apoptosis and enhances cell viability and monoclonal antibody expression in CHO-K1 cells., PMID:37286776
Serum circulating sirtuin 6 as a novel predictor of mortality after acute ischemic stroke., PMID:36443316
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
MicroRNA-338-3p as a novel therapeutic target for intervertebral disc degeneration., PMID:34531509
Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models., PMID:35782983
Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells., PMID:32535965
Potential therapeutic effects of cyanidin-3-O-glucoside on rheumatoid arthritis by relieving inhibition of CD38+ NK cells on Treg cell differentiation., PMID:31661005
NAD metabolism fuels human and mouse intestinal inflammation., PMID:28877980
Sirt6 alters adult hippocampal neurogenesis., PMID:28644902
Assessing the Histone Deacetylase Activity of SIRT6 in Primary Murine Hepatocytes via Proximity Ligation Assay., PMID:27761819
Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging., PMID:32262067
Expression of SIRT2 and SIRT6 in retinoblastoma., PMID:25660418
Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice., PMID:25658474
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer., PMID:25074979
The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain., PMID:24495875
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence., PMID:23201774
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence., PMID:22753495
Mechanism-based affinity capture of sirtuins., PMID:21184005
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice., PMID:20847051
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase., PMID:15795229
For research use only. Not for human or drug use.
