Catalog No.
PMA70801
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse CD258/TNFSF14/LIGHT (Asp72-Val239).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Herpes virus entry mediator ligand, LIGHT, CD258, HVEM-L, HVEML, TNFSF14, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator ligand
Purification
Purified by antigen affinity column.
Accession
Q9QYH9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome., PMID:34871182
Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS., PMID:32817460
Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents., PMID:32635185
Unique Sjögren's syndrome patient subsets defined by molecular features., PMID:31497844
LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens., PMID:30405638
LIGHT-HVEM signaling in keratinocytes controls development of dermatitis., PMID:29339444
DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression., PMID:28560426
Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis., PMID:28155222
A Randomized Phase 1 Study to Assess the Safety and Pharmacokinetics of the Subcutaneously Injected Anti-LIGHT Antibody, SAR252067., PMID:27545119
The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis., PMID:25789702
Therapeutic blockade of LIGHT interaction with herpesvirus entry mediator and lymphotoxin β receptor attenuates in vivo cytotoxic allogeneic responses., PMID:25226173
Reverse signaling from LIGHT promotes pro-inflammatory responses in the human monocytic leukemia cell line, THP-1., PMID:24044961
Serum-soluble herpes virus entry mediator levels reflect disease severity and Th2 environment in cutaneous T-cell lymphoma., PMID:23306973
Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT., PMID:21959263
Characterization of herpes virus entry mediator as a factor linked to obesity., PMID:19680232
From gene expression to serum proteins: biomarker discovery in ankylosing spondylitis., PMID:19103635
Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium., PMID:17938804
Targeting lymphotoxin beta receptor with tumor-specific T lymphocytes for tumor regression., PMID:17785576
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes., PMID:17393389
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure., PMID:16934497
LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis., PMID:16649193
Inhibition of lymphotoxin-beta receptor-mediated cell death by survivin-DeltaEx3., PMID:16540654
LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM., PMID:16275888
LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation., PMID:15549770
Attenuation of graft arterial disease by manipulation of the LIGHT pathway., PMID:15178556
[Eukaryotic expression of human LIGHT-Fc chimeric molecule and its anti-tumor activity]., PMID:15169669
The effect of LIGHT in inducing maturation of monocyte-derived dendritic cells from MDS patients., PMID:15103504
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy., PMID:15067315
A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis., PMID:12816989
The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death., PMID:12566458
LIGHT, a new member of the TNF superfamily., PMID:12456019
Mouse T cells receive costimulatory signals from LIGHT, a TNF family member., PMID:12384428
Recombinant, soluble LIGHT (HVEM ligand) induces increased IL-8 secretion and growth arrest in A375 melanoma cells., PMID:11429164
The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA., PMID:11164894
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response., PMID:10754304
Costimulatory wars: the tumor menace., PMID:11007364
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway., PMID:10700230
For research use only. Not for human or drug use.
