Catalog No.
PMK60201
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse KLK5 (Trp81-Asn293).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
KLK5, Stratum corneum tryptic enzyme, SCTE, Kallikrein-like protein 2, Kallikrein-5, KLK-L2
Purification
Purified by antigen affinity column.
Accession
Q9D140
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Blocking of IL-4/IL-13 Signalling With Dupilumab Results in Restoration of Serum and Cutaneous Abnormalities in Netherton Syndrome., PMID:40344324
Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis., PMID:40060399
Αnti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases., PMID:37987118
Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling., PMID:37684700
Overcoming Soluble Target Interference in Measurement of Total Bispecific Therapeutic Antibody Concentrations., PMID:37594571
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys., PMID:37353723
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis., PMID:36516271
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma., PMID:35487308
Rosacea Is Characterized by a Profoundly Diminished Skin Barrier., PMID:32199994
Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer., PMID:30114962
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases., PMID:29406699
Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis., PMID:28712126
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course., PMID:26345898
Episodic binge ethanol exposure impairs murine macrophage infiltration and delays wound closure by promoting defects in early innate immune responses., PMID:24689549
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome., PMID:24534191
SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation., PMID:24441102
Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation., PMID:24390132
Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis., PMID:21697885
Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response., PMID:19820362
Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein., PMID:19456860
Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest., PMID:18701499
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma., PMID:18182244
Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases., PMID:17625593
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction., PMID:17596512
Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients., PMID:17518992
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7., PMID:15140227
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids., PMID:12890555
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer., PMID:12873991
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?, PMID:10620116
Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation., PMID:10514489
For research use only. Not for human or drug use.
