Anti-Mouse CD146/MCAM Polyclonal Antibody

Catalog No.

PME39701

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD146/MCAM (Asp36-Val245).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

CD146, Melanoma cell adhesion molecule, S-endo 1 endothelial-associated antigen, Melanoma-associated antigen A32, MUC18, MCAM, Melanoma-associated antigen MUC18, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12

Purification

Purified by antigen affinity column.

Accession

Q8R2Y2

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

[Correlation between soluble CD146 and systemic vasculitis]., PMID:40484821

A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells., PMID:40316673

Extracellular Vesicles Analysis as Possible Signatures of Antiphospholipid Syndrome Clinical Features., PMID:40243411

Involvement of CD146 in the Cryptococcus neoformans adhesion and infection of brain endothelial cells., PMID:40208055

Antigen targeting and anti-tumor activity of a novel anti-CD146 212Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma., PMID:39472474

Hepatic Stellate Cell-mediated Increase in CCL5 Chemokine Expression after X-ray Irradiation Determined In Vitro and In Vivo., PMID:39449628

Soluble CD146 Cooperates with VEGFa to Generate an Immunosuppressive Microenvironment in CD146-Positive Tumors: Interest of a Combined Antibody-Based Therapy., PMID:39431288

Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling., PMID:39309216

The Blood-Brain Barrier in Both Humans and Rats: A Perspective From 3D Imaging., PMID:39224835

Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma., PMID:39077827

CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway., PMID:38908086

Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer., PMID:38902710

An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum., PMID:38599037

Evaluation of Circulating Endothelial Cells as Direct Marker of Endothelial Damage in Allo-Transplant Recipients at High Risk of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome., PMID:38582286

Plasma sCD146 is a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease., PMID:38476031

Exploring the Utility of Circulating Endothelial Cell-Derived Extracellular Vesicles as Markers of Health and Damage of Vasal Endothelium in Systemic Sclerosis Patients Treated with Iloprost., PMID:38397897

CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages., PMID:38109838

CD146-targeted nuclear medicine imaging in cancer: state of the art., PMID:38076327

CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway., PMID:37856423

Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization., PMID:37749499

CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis., PMID:37650914

Prognostic significance of circulating microparticles in IgA nephropathy., PMID:37615844

Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity., PMID:37484769

Regeneration of periodontal ligament fibers around mini dental implants and their attachment to the bone in an animal model: A radiographic and histological study., PMID:37152460

Microcirculation surrounding end-stage human chronic skin wounds is associated with endoglin/CD146/ALK-1 expression, endothelial cell proliferation and an absence of p16Ink4a., PMID:37017097

Neuroblastoma Tumor-Associated Mesenchymal Stromal Cells Regulate the Cytolytic Functions of NK Cells., PMID:36612020

Microvesicles released from ectopic endometrial foci as a potential biomarker of endometriosis., PMID:36448351

MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes., PMID:36319587

Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma., PMID:36274147

Immunotherapeutic Targeting of NG2/CSPG4 in Solid Organ Cancers., PMID:35891187

Exercise Training Effects on Circulating Endothelial and Progenitor Cells in Heart Failure., PMID:35877584

Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry., PMID:35716258

Soluble CD146 is increased in preeclampsia and interacts with galectin-1 to regulate trophoblast migration through VEGFR2 receptor., PMID:35559998

Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord., PMID:35325405

The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia., PMID:35306530

CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity., PMID:35258174

Cell Surface Proteins for Enrichment and In Vitro Characterization of Human Pluripotent Stem Cell-Derived Myogenic Progenitors., PMID:35251185

Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination., PMID:35055160

Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor., PMID:35001552

Comprehensive Immune Profiling Reveals CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease., PMID:34987111

Proliferation rate and expression of stem cells markers during expansion in primary culture of pulp cells., PMID:34878083

CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases., PMID:34729700

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells., PMID:34611477

CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4., PMID:34575887

CD146 is a potential immunotarget for neuroblastoma., PMID:34464480

Isolation and immunohistochemical characterization of periodontal ligament stem cells: A preliminary study., PMID:34393399

Recognize the role of CD146/MCAM in the osteosarcoma progression: an in vitro study., PMID:34103063

Differential expression of P63, P27, P57, Ki-67, and CD146 in hydropic and molar pregnancies., PMID:34057923

Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146., PMID:33997697

ImmunoPET of the differential expression of CD146 in breast cancer., PMID:33948375

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