Catalog No.
PME39701
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse CD146/MCAM (Asp36-Val245).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CD146, Melanoma cell adhesion molecule, S-endo 1 endothelial-associated antigen, Melanoma-associated antigen A32, MUC18, MCAM, Melanoma-associated antigen MUC18, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12
Purification
Purified by antigen affinity column.
Accession
Q8R2Y2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
[Correlation between soluble CD146 and systemic vasculitis]., PMID:40484821
A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells., PMID:40316673
Extracellular Vesicles Analysis as Possible Signatures of Antiphospholipid Syndrome Clinical Features., PMID:40243411
Involvement of CD146 in the Cryptococcus neoformans adhesion and infection of brain endothelial cells., PMID:40208055
Antigen targeting and anti-tumor activity of a novel anti-CD146 212Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma., PMID:39472474
Hepatic Stellate Cell-mediated Increase in CCL5 Chemokine Expression after X-ray Irradiation Determined In Vitro and In Vivo., PMID:39449628
Soluble CD146 Cooperates with VEGFa to Generate an Immunosuppressive Microenvironment in CD146-Positive Tumors: Interest of a Combined Antibody-Based Therapy., PMID:39431288
Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling., PMID:39309216
The Blood-Brain Barrier in Both Humans and Rats: A Perspective From 3D Imaging., PMID:39224835
Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma., PMID:39077827
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway., PMID:38908086
Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer., PMID:38902710
An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum., PMID:38599037
Evaluation of Circulating Endothelial Cells as Direct Marker of Endothelial Damage in Allo-Transplant Recipients at High Risk of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome., PMID:38582286
Plasma sCD146 is a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease., PMID:38476031
Exploring the Utility of Circulating Endothelial Cell-Derived Extracellular Vesicles as Markers of Health and Damage of Vasal Endothelium in Systemic Sclerosis Patients Treated with Iloprost., PMID:38397897
CD146 deficiency aggravates chronic obstructive pulmonary disease via the increased production of S100A9 and MMP-9 in macrophages., PMID:38109838
CD146-targeted nuclear medicine imaging in cancer: state of the art., PMID:38076327
CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway., PMID:37856423
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization., PMID:37749499
CD146 deficiency promotes inflammatory type 2 responses in pulmonary cryptococcosis., PMID:37650914
Prognostic significance of circulating microparticles in IgA nephropathy., PMID:37615844
Pulmonary arterial hypertension in children with congenital heart disease: a deeper look into the role of endothelial progenitor cells and circulating endothelial cells to assess disease severity., PMID:37484769
Regeneration of periodontal ligament fibers around mini dental implants and their attachment to the bone in an animal model: A radiographic and histological study., PMID:37152460
Microcirculation surrounding end-stage human chronic skin wounds is associated with endoglin/CD146/ALK-1 expression, endothelial cell proliferation and an absence of p16Ink4a., PMID:37017097
Neuroblastoma Tumor-Associated Mesenchymal Stromal Cells Regulate the Cytolytic Functions of NK Cells., PMID:36612020
Microvesicles released from ectopic endometrial foci as a potential biomarker of endometriosis., PMID:36448351
MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes., PMID:36319587
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma., PMID:36274147
Immunotherapeutic Targeting of NG2/CSPG4 in Solid Organ Cancers., PMID:35891187
Exercise Training Effects on Circulating Endothelial and Progenitor Cells in Heart Failure., PMID:35877584
Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry., PMID:35716258
Soluble CD146 is increased in preeclampsia and interacts with galectin-1 to regulate trophoblast migration through VEGFR2 receptor., PMID:35559998
Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord., PMID:35325405
The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia., PMID:35306530
CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity., PMID:35258174
Cell Surface Proteins for Enrichment and In Vitro Characterization of Human Pluripotent Stem Cell-Derived Myogenic Progenitors., PMID:35251185
Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination., PMID:35055160
Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor., PMID:35001552
Comprehensive Immune Profiling Reveals CD56+ Monocytes and CD31+ Endothelial Cells Are Increased in Severe COVID-19 Disease., PMID:34987111
Proliferation rate and expression of stem cells markers during expansion in primary culture of pulp cells., PMID:34878083
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases., PMID:34729700
Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells., PMID:34611477
CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4., PMID:34575887
CD146 is a potential immunotarget for neuroblastoma., PMID:34464480
Isolation and immunohistochemical characterization of periodontal ligament stem cells: A preliminary study., PMID:34393399
Recognize the role of CD146/MCAM in the osteosarcoma progression: an in vitro study., PMID:34103063
Differential expression of P63, P27, P57, Ki-67, and CD146 in hydropic and molar pregnancies., PMID:34057923
Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146., PMID:33997697
ImmunoPET of the differential expression of CD146 in breast cancer., PMID:33948375