Catalog No.
PHD00901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTPN22 (Met1-Gly303).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
PTPN8, Lymphoid phosphatase, PTPN22, PEST-domain phosphatase, LyP, Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEP
Purification
Purified by antigen affinity column.
Accession
Q9Y2R2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers., PMID:40485950
From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis., PMID:40236704
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., PMID:39083881
Machine learning-based prediction of rheumatoid arthritis with development of ACPA autoantibodies in the presence of non-HLA genes polymorphisms., PMID:38517871
Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India., PMID:38483572
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion., PMID:38056892
Association between PYTPN22 rs2476601, VEGF rs833070, TNFAIP3 rs6920220 Polymorphisms and Risk for Rheumatoid Arthritis in Early Undifferentiated Arthritis Patients: A Pilot Study., PMID:37893542
Genetic variants and risk of endocrine autoimmunity in relatives of patients with Addison's disease., PMID:37010089
CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients., PMID:36622793
The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis Update with Trial Sequential Analysis., PMID:36306511
Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study., PMID:36150053
Genetic basis of defects in immune tolerance underlying the development of autoimmunity., PMID:35979360
IgA-Type Enterovirus Antibodies Are Increased among Adults and Children with Recently Diagnosed Type 1 Diabetes., PMID:35958821
GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases., PMID:35933036
Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects., PMID:35812428
Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes., PMID:35403376
Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study., PMID:35074870
Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes., PMID:35008834
Cellular and molecular basis of thyroid autoimmunity., PMID:34981746
PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking., PMID:34733271
Characterization of Organ-Specific Regulatory B Cells Using Single-Cell RNA Sequencing., PMID:34594327
Causal risk and protective factors in rheumatoid arthritis: A genetic update., PMID:34522877
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study., PMID:34291312
Genetic Factors of Predisposition and Clinical Characteristics of Rheumatoid Arthritis in Russian Patients., PMID:34070522
Moderating Role of TSHR and PTPN22 Gene Polymorphisms in Effects of Excessive Fluoride on Thyroid: a School-Based Cross-Sectional Study., PMID:34050454
Understanding interactions between risk factors, and assessing the utility of the additive and multiplicative models through simulations., PMID:33901204
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis., PMID:33841406
Altered Antibody Response to Epstein-Barr Virus in Patients With Rheumatoid Arthritis and Healthy Subjects Predisposed to the Disease. A Twin Study., PMID:33777048
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia., PMID:33686257
Validation of a Bioassay for Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis., PMID:33426780
Co-Occurrence of ANCA-Associated Vasculitis and Sjögren's Syndrome in a Patient With Acromegaly: A Case Report and Retrospective Single-Center Review of Acromegaly Patients., PMID:33408719
Classical Examples of the Concept of the ASIA Syndrome., PMID:33053910
Distinct HLA and non-HLA associations in different subtypes of ANCA-associated vasculitides in North India., PMID:32297471
PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling., PMID:32184287
PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion., PMID:32047502
Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells., PMID:31808541
Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia., PMID:31798789
Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases., PMID:31616406
An investigation of polymorphisms in innate and adaptive immune response genes in canine leishmaniosis., PMID:31079826
Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report., PMID:30967432
Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review., PMID:30904715
Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach., PMID:30871019
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study., PMID:30327147
T Helper 1 Cellular Immunity Toward Recoverin Is Enhanced in Patients With Active Autoimmune Retinopathy., PMID:30271775
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens., PMID:30139951
Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses., PMID:30054208
Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs., PMID:29924845
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients., PMID:29895027
For research use only. Not for human or drug use.
