Anti-Human C1GALT1C1 Polyclonal Antibody

Catalog No.

PHN30701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C1GALT1C1 (His41-Asp318).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

C1Gal-T2, Core 1 beta1,3-galactosyltransferase 2, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C38H2-L1, C1GALT1C1, COSMC, C38H2-like protein 1, Core 1 beta3-Gal-T2, C1GalT2, C1GALT1-specific chaperone 1

Purification

Purified by antigen affinity column.

Accession

Q96EU7

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma., PMID:38254730

CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation., PMID:36648436

A case of Tn polyagglutination discovered by an ABO blood group discrepancy., PMID:35748659

CD44-Associated Tn Antigen as a New Biomarker of Tumor Cells with Aberrant Glycosylation., PMID:33050853

MicroRNA‑196b targets COSMC in pediatric IgA nephropathy., PMID:32186752

C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy., PMID:31941451

Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression., PMID:31250447

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers., PMID:30115016

Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells., PMID:29299950

MiR-320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathy., PMID:29266359

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway., PMID:28187132

TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc., PMID:28035353

MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy., PMID:27796698

Potential diagnostic biomarkers for IgA nephropathy: a comparative study pre- and post-tonsillectomy., PMID:27465795

Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated IgA1 in B cells of IgA nephropathy., PMID:26545495

Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29., PMID:26045765

DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy., PMID:25647400

Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients., PMID:25167771

Astragalus membranaceus up-regulate Cosmc expression and reverse IgA dys-glycosylation in IgA nephropathy., PMID:24942185

CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells., PMID:24462875

[Progression in the mechanism of the Cosmc in IgA nephropathy]., PMID:24267143

Activation of the interleukin-4/signal transducer and activator of transcription 6 signaling pathway and homeodomain-interacting protein kinase 2 production by tonsillar mononuclear cells in IgA nephropathy., PMID:24107646

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing., PMID:24039759

Mycophenolic acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA nephropathy., PMID:23136028

Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells., PMID:22143985

Down-regulation of core 1 beta1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1., PMID:20551088

Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy., PMID:20538527

The role of C1GALT1C1 in lipopolysaccharide-induced IgA1 aberrant O-glycosylation in IgA nephropathy., PMID:20144270

External suppression causes the low expression of the Cosmc gene in IgA nephropathy., PMID:18202089

Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc., PMID:18061573

Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy., PMID:17228361

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