Catalog No.
PHG13901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SOS1 (Gln566-Arg1046).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SOS1, Son of sevenless homolog 1, SOS-1
Purification
Purified by antigen affinity column.
Accession
Q07889
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma., PMID:39488215
Allosteric nanobodies to study the interactions between SOS1 and RAS., PMID:39043660
MicroRNA-focused CRISPR/Cas9 screen identifies miR-142 as a key regulator of Epstein-Barr virus reactivation., PMID:38885264
FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2., PMID:34697226
Subcellular Dynamic Immunopatterning of Cytosolic Protein Complexes on Microstructured Polymer Substrates., PMID:34652152
KRAS mutations in metastatic colorectal cancer: from a de facto ban on anti-EGFR treatment in the past to a potential biomarker for precision medicine., PMID:34378483
Magnetic spatiotemporal control of SOS1 coupled nanoparticles for guided neurite growth in dopaminergic single cells., PMID:33384447
Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation., PMID:30615681
Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression-induced apoptosis in hepatoma cells., PMID:28351301
Kindlin-2 regulates renal tubular cell plasticity by activation of Ras and its downstream signaling., PMID:24226523
Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature., PMID:23786871
Laminin-α1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-κB transcription factors but also has adverse effects., PMID:22159078
Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling., PMID:16475793
PECAM-1 isoform-specific activation of MAPK/ERKs and small GTPases: implications in inflammation and angiogenesis., PMID:16440301
Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells., PMID:15736129
Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos., PMID:15305288
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling., PMID:14676298
Regulation of vacuolar Na+/H+ exchange in Arabidopsis thaliana by the salt-overly-sensitive (SOS) pathway., PMID:14570921
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway., PMID:14565974
Skeletal muscle signaling pathway through the dystrophin glycoprotein complex and Rac1., PMID:12885773
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling., PMID:12486104
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses., PMID:12194965
Fibroblast growth factor receptor (FGFR) and candidate signaling molecule distribution within rat and human retina., PMID:12097864
Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle., PMID:12008030
Critical role of extracellular signal-regulated kinase phosphorylation on menadione (vitamin K3) induced growth inhibition., PMID:11267961
Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1., PMID:10913276
The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1., PMID:9372945
Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils., PMID:9353345
A simple improvement in expression cloning., PMID:9212173
Fas-signaling and effects on receptor tyrosine kinase signal transduction in human breast epithelial cells., PMID:9020068
Immunohistochemical localization of signal transduction pathways during amelogenesis: an initial exploration., PMID:9206326
Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor., PMID:8910327
Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking., PMID:8695800
Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines., PMID:8649802
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells., PMID:7791764
Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin., PMID:7744881
Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin., PMID:7829473
B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation., PMID:7525306
The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation., PMID:8178446
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase., PMID:8106439
Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors., PMID:8289791
For research use only. Not for human or drug use.
