Catalog No.
PHD26201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TPH1 (Met1-Ile444).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TRPH, TPH1, TPRH, TPH
Purification
Purified by antigen affinity column.
Accession
P17752
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques., PMID:15199371
Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons., PMID:15246835
Influence of polysaccharide coating on the interactions of nanoparticles with biological systems., PMID:16118015
Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies., PMID:16581041
Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice., PMID:17256748
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice., PMID:17622221
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II., PMID:17727633
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding., PMID:17973628
Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain., PMID:18839395
Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia., PMID:19015006
Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain., PMID:19233335
Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease., PMID:19301552
A novel murine model of severe pulmonary arterial hypertension., PMID:21868504
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice., PMID:22330338
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension., PMID:22525513
Neuronal serotonin regulates growth of the intestinal mucosa in mice., PMID:22609381
Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition., PMID:22819790
Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity., PMID:23182718
Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells., PMID:24468700
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism., PMID:24558199
Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine., PMID:24603700
Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice., PMID:24700614
Disease specificity of anti-tryptophan hydroxylase-1 and anti-AIE-75 autoantibodies in APECED and IPEX syndrome., PMID:25463430
Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED., PMID:25805658
[Difference in target antigens between central tolerance and peripheral tolerance deficiencies]., PMID:26213192
Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish., PMID:26437856
Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites., PMID:29576437
Increase in chromogranin A- and serotonin-positive cells in pouch mucosa of patients with ulcerative colitis undergoing proctocolectomy., PMID:29803758
Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments., PMID:29849496
[Metabolic analysis of serotonin system in serum and gastric tissues of ovalbumin-induced allergic mice]., PMID:29973322
PD-1+CXCR5-CD4+T cells are correlated with the severity of systemic lupus erythematosus., PMID:31180450
IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro., PMID:31519333
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor., PMID:33432230
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury., PMID:34507634
TPH1 and 5-HT7 Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma., PMID:34771469
Triptófano-5-hidroxilasa, transportador de serotonina y receptores serotoninérgicos en miocardiopatía dilatada., PMID:36472833
Hypertrophic cardiomyopathy induces changes in the tryptophan-5-hydroxylase, serotonin transporter and serotonergic receptors expressions., PMID:36657118
Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder., PMID:37536049
Serological Investigation of Persistent Villous Atrophy in Celiac Disease., PMID:37753949
CD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica., PMID:38350043
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520
Mast cells help organize the Peyer's patch niche for induction of IgA responses., PMID:38427721
For research use only. Not for human or drug use.
