Catalog No.
YMA70801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Asp72-Val239
Predicted molecular weight
20.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9QYH9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Herpes virus entry mediator ligand, LIGHT, CD258, HVEM-L, HVEML, TNFSF14, Tumor necrosis factor ligand superfamily member 14, Herpesvirus entry mediator ligand
Zhang, J., Xiong, X., Li, J., Luo, C., Su, Q., Hao, X., Wu, Q., and Huang, W. (2024). Valtrate suppresses TNFSF14-mediated arrhythmia after myocardial ischemia-reperfusion via inducing N-linked glycosylation of LTβR to regulate MGA/MAX/c-Myc/Cx43. J Cardiovasc Pharmacol.
Targeting B and T lymphocyte attenuator in cancer immunotherapy., PMID:40480574
Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis., PMID:40127640
Clinical Significance of TNFSF14/LIGHT and CD160 in Gastric Cancer and Peptic Ulcer Dyspepsia., PMID:39205564
Multilayered Computational Framework for Designing Peptide Inhibitors of HVEM-LIGHT Interaction., PMID:38958133
Systemic inflammatory cytokine profiles in patients with gout during flare, intercritical and treat-to-target phases: TNFSF14 as new biomarker., PMID:38373842
TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study., PMID:38235898
Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis., PMID:37722959
LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells., PMID:37552689
High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome., PMID:36917420
Elevated Levels of the Cytokine LIGHT in Pediatric Crohn's Disease., PMID:36688686
Comprehensive characterization of TNFSF14/LIGHT with implications in prognosis and immunotherapy of human gliomas., PMID:36341396
A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion., PMID:35987137
LIGHT (TNFSF14) Costimulation Enhances Myeloid Cell Activation and Antitumor Immunity in the Setting of PD-1/PD-L1 and TIGIT Checkpoint Blockade., PMID:35817517
Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway., PMID:35292636
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome., PMID:34871182
The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts., PMID:34838790
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160., PMID:34709351
Changes in Cerebrospinal Fluid Balance of TNF and TNF Receptors in Naïve Multiple Sclerosis Patients: Early Involvement in Compartmentalised Intrathecal Inflammation., PMID:34359880
Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility., PMID:34353742
Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles., PMID:34244107
The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps., PMID:34083106
LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells., PMID:33606781
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells., PMID:33594067
Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients., PMID:33542721
Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage., PMID:33492677
LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis., PMID:33045563
Efficient Expansion of Human Granzyme B-Expressing B Cells with Potent Regulatory Properties., PMID:32948686
LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-κB pathway., PMID:32881263
Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS., PMID:32817460
Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160., PMID:32795404
The impact of TNFSF14 on prognosis and immune microenvironment in clear cell renal cell carcinoma., PMID:32725578
Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype., PMID:32712105
Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents., PMID:32635185
TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy., PMID:32499782
Identification of immunologic subtype and prognosis of GBM based on TNFSF14 and immune checkpoint gene expression profiling., PMID:32310827
TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation., PMID:32118359
Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury., PMID:32059364
Neonatal Antibiotic Treatment Is Associated With an Altered Circulating Immune Marker Profile at 1 Year of Age., PMID:31998285
LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss., PMID:31990039
LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients., PMID:31826304
Unique Sjögren's syndrome patient subsets defined by molecular features., PMID:31497844
Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia., PMID:31300808
The Absence of Lymphotoxin-α, a Herpesvirus Entry Mediator (HVEM) Ligand, Affects Herpes Simplex Virus 1 Infection In Vivo Differently than the Absence of Other HVEM Cellular Ligands., PMID:31142672
Circulating TNFSF14 (Tumor Necrosis Factor Superfamily 14) Predicts Clinical Outcome in Patients With Stable Coronary Artery Disease., PMID:30943772
LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens., PMID:30405638
Green light and light stress in moth: influence on antioxidant enzymes in the oriental armyworm, Mythimna separata (Lepidoptera: Noctuidae)., PMID:30328544
Shedding Light on the Shade: How Nurseries Protect Their Children from Ultraviolet Radiation., PMID:30134509
Circulating soluble LIGHT/TNFSF14 is increased and associated with IL-8 concentration in chronic spontaneous urticaria., PMID:29952668
Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study., PMID:29940819
TNFSF14 inhibits melanogenesis via NF-kB signaling in melanocytes., PMID:29730385
For research use only. Not for human or drug use.
