Catalog No.
PHH38901
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTPRN (Met389-Arg575).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ICA512-TMF,ICA512-CCF,Receptor-type tyrosine-protein phosphatase-like N,Islet cell autoantigen 3,ICA512,PTPRN,Islet cell antigen 512,ICA 512,PTP IA-2,ICA3,ICA512-NTF,R-PTP-N
Purification
Purified by antigen affinity column.
Accession
Q16849
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
General population screening for type 1 diabetes using islet autoantibodies at the preschool vaccination visit: a proof-of-concept study (the T1Early study)., PMID:38925883
Development of an ostrich-derived single-chain variable fragment (scFv) against PTPRN extracellular domain., PMID:38355744
Non-HLA Antibodies and Their Role in Highly Sensitized Patients., PMID:36319497
Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea., PMID:35263538
Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target., PMID:35040477
Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives., PMID:34448034
Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample., PMID:34338806
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study., PMID:34291312
The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)., PMID:33893822
Diagnostic value of combined islet antigen-reactive T cells and autoantibodies assays for type 1 diabetes mellitus., PMID:33064907
Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8., PMID:32696593
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity., PMID:32613719
Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes?, PMID:32451571
Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population., PMID:31276222
Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes., PMID:31167877
Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot., PMID:31152768
Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes., PMID:30588857
Autoantibodies against ZnT8 are rare in Central-European LADA patients and absent in MODY patients, including those positive for other autoantibodies., PMID:30377089
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes., PMID:30327357
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients., PMID:29895027
Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?, PMID:29487039
Construction of a novel vaccine by conjugating a B-cell epitope of DPP4 to peptide IA2(5)-P2-1 to significantly control type 1 diabetes in NOD mice., PMID:29169891
'25-Hydroxyvitamin D, Autoantigenic and Total Antibody Concentrations: Results from a Danish Case-control Study of Newly Diagnosed Patients with Childhood Type 1 Diabetes and their Healthy Siblings'., PMID:29125655
Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies., PMID:28941965
Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany., PMID:28370329
Identification of Unique Antigenic Determinants in the Amino Terminus of IA-2 (ICA512) in Childhood and Adult Autoimmune Diabetes: New Biomarker Development., PMID:28174261
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity., PMID:27872147
3 Screen islet cell autoantibody ELISA: A sensitive and specific ELISA for the combined measurement of autoantibodies to GAD65, to IA-2 and to ZnT8., PMID:27570064
3 Screen ELISA for High-Throughput Detection of Beta Cell Autoantibodies in Capillary Blood., PMID:27552135
The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2)., PMID:27329026
Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study., PMID:27311490
The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients., PMID:27225179
Tetraspanin 7 autoantibodies in type 1 diabetes., PMID:27221092
Capillary blood islet autoantibody screening for identifying pre-type 1 diabetes in the general population: design and initial results of the Fr1da study., PMID:27194320
Molecular Methods and Protein Synthesis for Definition of Autoantibody Epitopes., PMID:27032951
Validation of a rapid type 1 diabetes autoantibody screening assay for community-based screening of organ donors to identify subjects at increased risk for the disease., PMID:27029857
Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes., PMID:26564179
Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study., PMID:26375197
Saffold Virus, a Human Cardiovirus, and Risk of Persistent Islet Autoantibodies in the Longitudinal Birth Cohort Study MIDIA., PMID:26317929
Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies., PMID:26313035
Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: Implications for determinant spreading., PMID:26071317
Biomarkers related to severe hypoglycaemia and lack of good glycaemic control in ACCORD., PMID:25652389
HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes., PMID:25225671
A rapid lateral flow immunoassay for the detection of tyrosine phosphatase-like protein IA-2 autoantibodies in human serum., PMID:25047039
Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients., PMID:24332797
Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes., PMID:24001205
[A case of elderly-onset type 1 diabetes mellitus: negative for antiglutamic acid dehydrogenase antibody and positive insulinoma-associated tyrosine phosphatase-like protein-2 antibody]., PMID:23979349
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children., PMID:23780460
Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay., PMID:23696946
Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study., PMID:23469940
For research use only. Not for human or drug use.
