Catalog No.
YHN35901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg210
Predicted molecular weight
26.09 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2L1
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RRP44, Ribosomal RNA-processing protein 44, DIS3, KIAA1008, Exosome complex exonuclease RRP44, Protein DIS3 homolog
Note
For research use only.
Yeast RNA exosome activity is necessary for maintaining cell wall stability through proper protein glycosylation., PMID:33439673
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells., PMID:33526923
DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome., PMID:33951891
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis., PMID:34059908
Interplay of the RNA Exosome Complex and RNA-Binding Protein Ssd1 in Maintaining Cell Wall Stability in Yeast., PMID:34259554
Somatic reversion impacts myelodysplastic syndromes and acute myeloid leukemia evolution in the short telomere disorders., PMID:34343137
Epidemiology, genetics and treatment of multiple myeloma and precursor diseases., PMID:34398972
Reproducible and efficient new method of RNA 3'-end labelling by CutA nucleotidyltransferase-mediated CC-tailing., PMID:34766865
Reverse Genetic Screen for Deleterious Recessive Variants in the Local Simmental Cattle Population of Switzerland., PMID:34944310
piRNAs Interact with Cold-Shock Domain-Containing RNA Binding Proteins and Regulate Neuronal Gene Expression During Differentiation., PMID:34982407
How hydrolytic exoribonucleases impact human disease: Two sides of the same story., PMID:35247037
MicroRNA-125a/b-5p promotes malignant behavior in multiple myeloma cells and xenograft tumor growth by targeting DIS3., PMID:35394705
Genetic changes associated with relapse in favorable histology Wilms tumor: A Children's Oncology Group AREN03B2 study., PMID:35617957
RNA exosome drives early B cell development via noncoding RNA processing mechanisms., PMID:35658015
Defining pervasive transcription units using chromatin RNA-sequencing data., PMID:35693207
Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders in Thailand Population., PMID:35770320
MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus., PMID:35902094
Molecular fingerprints of polar narcotic chemicals based on heterozygous essential gene knockout library in Saccharomyces cerevisiae., PMID:36087727
Genome-Wide Screening and Stability Verification of the Robust Internal Control Genes for RT-qPCR in Filamentous Fungi., PMID:36135677
Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias., PMID:36138464
TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review., PMID:36181538
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism., PMID:36215697
Advances in the molecular characterization of multiple myeloma and mechanism of therapeutic resistance., PMID:36387095
MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing., PMID:36403484
RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation., PMID:36724075
DIS3: The Enigmatic Gene in Multiple Myeloma., PMID:36835493
In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 in Saccharomyces cerevisiae., PMID:36861343
DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis., PMID:36869713
Epididymal DIS3 exosome ribonuclease is not necessary for mouse sperm maturation or fertility., PMID:37172450
Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception., PMID:37192170
A genomic score to predict local control among patients with brain metastases managed with radiation., PMID:37260393
Proteomic analysis of STEAP1 knockdown in human LNCaP prostate cancer cells., PMID:37315586
DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification., PMID:37439377
Effect of MAPK activation via mutations in NRAS, KRAS and BRAF on clinical outcome in newly diagnosed multiple myeloma., PMID:37452600
Reduced female fertility due to sequestration of RNA Pol II by pervasive transcription in exosome RNase-depleted oocytes., PMID:37831603
Copy number variants landscape of multiple cancers and clinical applications based on NGS gene panel., PMID:37967237
Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma., PMID:38252427
Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export., PMID:38306394
Engineering stringent genetic biocontainment of yeast with a protein stability switch., PMID:38316765
DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice., PMID:38953252
ZC3H4/Restrictor Exerts a Stranglehold on Pervasive Transcription., PMID:39002716
Functional characterization of human recessive DIS3 variants in premature ovarian insufficiency†., PMID:39400047
Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer., PMID:39408874
A Comparative Overview of the Role of Human Ribonucleases in Nonsense-Mediated mRNA Decay., PMID:39457432
Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation., PMID:39800708
The ER-PM interaction is essential for cytokinesis and recruits the actin cytoskeleton through the SCAR/WAVE complex., PMID:39913210
Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach., PMID:40399278
Dis3l2 is essential for neural crest survival by modulating Akt signaling., PMID:40500755
EXOSC3 S1-domain variants implicated in PCH1b alter RNA exosome cap subunit abundance and thermal stability disrupting rRNA processing and targeting of AU-rich mRNA., PMID:40501579
For research use only. Not for human or drug use.
