Catalog No.
YHN35101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg11-Ser285
Predicted molecular weight
34.00 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UIV1
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CNOT7, BTG1-binding factor 1, CAF-1, CAF1, Caf1a, CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1
Note
For research use only.
CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay., PMID:29956766
A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis., PMID:30423293
CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte., PMID:30478191
Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex., PMID:30703164
Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis., PMID:30918060
1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg2+-dependent binding., PMID:30984545
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway., PMID:31155293
DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity., PMID:31180491
Differently Expressed Genes (DEGs) Relevant to Type 2 Diabetes Mellitus Identification and Pathway Analysis via Integrated Bioinformatics Analysis., PMID:31797865
Daisy Chain Topology Based Mammalian Synthetic Circuits for RNA-Only Delivery., PMID:31895544
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability., PMID:31924127
CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma., PMID:32160402
Silencing of CCR4-NOT complex subunits affects heart structure and function., PMID:32471864
Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility., PMID:32502391
Triciribine Engages ZFP36L1 and HuR to Stabilize LDLR mRNA., PMID:33019656
Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma., PMID:33021411
Reprogramming of the histone H3.3 landscape in the early mouse embryo., PMID:33169018
MicroRNA-126-5p Inhibits the Migration of Breast Cancer Cells by Directly Targeting CNOT7., PMID:33256566
CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway., PMID:33412213
Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology., PMID:33757599
The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis., PMID:34026442
Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex., PMID:34038562
Identification of Key Circulating Exosomal microRNAs in Gastric Cancer., PMID:34336682
Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells., PMID:34589286
A novel homozygous missense variant in BTG4 causes zygotic cleavage failure and female infertility., PMID:34647228
PABPN1L assemble into "ring-like" aggregates in the cytoplasm of MII oocytes and is associated with female infertility†., PMID:34726234
Fetal Neuroprotective Mechanism of Maternal Magnesium Sulfate: Proteomic Analysis., PMID:34761370
CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development., PMID:34788619
Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements., PMID:34923703
Lowly expressed LNC01136 fails to aid HIF-1α to induce BTG2 expression resulting in increased proliferation of retinal microvascular endothelial cells., PMID:35007537
Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?†., PMID:35098307
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7)., PMID:35156522
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex., PMID:35248544
Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties., PMID:35575378
Structural Model of the Human BTG2-PABPC1 Complex by Combining Mutagenesis, NMR Chemical Shift Perturbation Data and Molecular Docking., PMID:35640718
MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma., PMID:36112698
Cytidine-containing tails robustly enhance and prolong protein production of synthetic mRNA in cell and in vivo., PMID:36320322
CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans., PMID:36797658
Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling., PMID:37424831
Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability., PMID:37508532
The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs., PMID:37767629
RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts., PMID:37989221
Engineered Protease-Responsive RNA-Binding Proteins (RBPs) to Expand the Toolbox of Synthetic Circuits in Mammalian Cells., PMID:38441758
CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease., PMID:38772212
Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes., PMID:38956014
Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma., PMID:38985240
Building a translational cancer dependency map for The Cancer Genome Atlas., PMID:39009815
NPPC and AREG supplementation in IVM systems alter mRNA translation and decay programs-related gene expression in bovine COC., PMID:39021501
Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease., PMID:39339346
The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT., PMID:39699231
For research use only. Not for human or drug use.
