Catalog No.
YHN34601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn65-Arg281
Predicted molecular weight
28.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZT2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein 7-60, Zeta-type opioid receptor, OGFr, Opioid growth factor receptor, OGFR
Note
For research use only.
Mutations in the opioid growth factor receptor in human cancers alter receptor function., PMID:26005722
Duration of opioid receptor blockade determines biotherapeutic response., PMID:26119823
Opioid growth factor and low-dose naltrexone impair central nervous system infiltration by CD4 + T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis., PMID:26202376
Featured Article: Nuclear export of opioid growth factor receptor is CRM1 dependent., PMID:26429201
Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts., PMID:26687326
Morphine Suppresses Lung Cancer Cell Proliferation Through the Interaction with Opioid Growth Factor Receptor: An In Vitro and Human Lung Tissue Study., PMID:27167686
The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes-The Lorenz E. Zimmerman Tribute Lecture., PMID:27703986
Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β-endorphin and methionine-enkephalin., PMID:28039905
Selective opioid growth factor receptor antagonists based on a stilbene isostere., PMID:28693915
Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid Growth Factor Receptor (OGFr)., PMID:29079719
Featured Article: Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis., PMID:29307283
Tranexamic acid inhibits the plasma and non-irradiated skin markers of photoaging induced by long-term UVA eye irradiation in female mice., PMID:30081203
Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue., PMID:30246052
Methionine enkephalin (MENK) inhibits human gastric cancer through regulating tumor associated macrophages (TAMs) and PI3K/AKT/mTOR signaling pathway inside cancer cells., PMID:30343258
The novel mechanism of anticancer effect on gastric cancer through inducing G0/G1 cell cycle arrest and caspase-dependent apoptosis in vitro and in vivo by methionine enkephalin., PMID:30425572
Intermittent blockade of OGFr and treatment of autoimmune disorders., PMID:30541348
Systemic administration of low-dose naltrexone increases bone mass due to blockade of opioid growth factor receptor signaling in mice osteoblasts., PMID:30930116
Blockade of the OGF-OGFr pathway in diabetic bone., PMID:30931654
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy., PMID:31404891
Prospective oncotarget for gynecological cancer: Opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis., PMID:31408839
Long noncoding RNA LINC00673 promotes the proliferation and metastasis of epithelial ovarian cancer by associating with opioid growth factor receptor., PMID:31496722
The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response., PMID:31835085
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway., PMID:32171145
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo., PMID:32585612
Dysregulation of the OGF-OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat., PMID:32640891
Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications., PMID:33203224
Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer., PMID:33220939
Methionine enkephalin activates autophagy and stimulates tumour cell immunogenicity in human cutaneous squamous cell carcinoma., PMID:33965882
Methionine enkephalin (MENK) suppresses lung cancer by regulating the Bcl-2/Bax/caspase-3 signaling pathway and enhancing natural killer cell-driven tumor immunity., PMID:34116288
Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma., PMID:34311187
Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin., PMID:34324868
Research progress of opioid growth factor in immune-related diseases and cancer diseases., PMID:34426103
Evolution and Genetic Diversity of the Retroviral Envelope in Anamniotes., PMID:35389232
Opioid Receptor Expression in Colorectal Cancer: A Nested Matched Case-Control Study., PMID:35463331
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by chemotherapy., PMID:35541895
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?, PMID:35648340
Methionine enkephalin inhibits colorectal cancer by remodeling the immune status of the tumor microenvironment., PMID:35988519
Superior Anticancer Potential of Nano-Paclitaxel Combined Bevacizumab Treatment in Ovarian Cancer., PMID:36221878
Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain., PMID:36812665
Opioid growth factor receptor promotes adipose tissue thermogenesis via enhancing lipid oxidation., PMID:39872016
Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice., PMID:37166576
Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia., PMID:37610843
In vitro and in vivo killing effects of methionine enkephalin on osteosarcoma., PMID:37976597
Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals the Immunotherapeutic Value of Toll-Like Receptor 4., PMID:38034898
Topical naltrexone increases aquaporin 5 production in the lacrimal gland and restores tear production in diabetic rats., PMID:38756167
Targeting OGF/OGFR signal to mitigate doxorubicin-induced cardiotoxicity., PMID:39122201
Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells., PMID:39801218
Identification of Potential Therapeutic Targets for Sensorineural Hearing Loss and Evaluation of Drug Development Potential Using Mendelian Randomization Analysis., PMID:40001646
Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways., PMID:40062813
Revealing Stress Granule Compositional Heterogeneity through Antibody-Guided Proximity Labeling., PMID:40198209
For research use only. Not for human or drug use.
