Catalog No.
PHH20101
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SMAD1 (Asp259-Ser462).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
BSP1,Mothers against DPP homolog 1,Mothers against decapentaplegic homolog 1,SMAD1,Transforming growth factor-beta-signaling protein 1,MADH1,JV4-1,MADR1,SMAD family member 1,hSMAD1,SMAD 1,MAD homolog 1,Mad-related protein 1,BSP-1,Smad1
Purification
Purified by antigen affinity column.
Accession
Q15797
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
A Role for Leucine-Rich α2-Glycoprotein in Leukocyte Trafficking and Mucosal Inflammation in Inflammatory Bowel Disease., PMID:39918378
A Recombinant Antibody Against ALK2 Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation., PMID:39791515
A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling., PMID:39196179
Zinc transporter ZnT5 is associated with epithelial mesenchymal transition via SMAD1 in breast cancer., PMID:39138630
Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA., PMID:38797268
Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis., PMID:38540766
Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis., PMID:37432984
Endoglin and squamous cell carcinomas., PMID:37396898
Loss of AID exacerbates the malignant progression of CLL., PMID:36042317
Mechanical Stretch Induced Osteogenesis on Human Annulus Fibrosus Cells through Upregulation of BMP-2/6 Heterodimer and Activation of P38 and SMAD1/5/8 Signaling Pathways., PMID:36010676
Curcuminoids Inhibit Angiogenic Behaviors of Human Umbilical Vein Endothelial Cells via Endoglin/Smad1 Signaling., PMID:35409247
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis., PMID:35167418
Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation., PMID:35163520
Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition., PMID:34845375
Nerve growth factor promotes osteogenic differentiation of MC3T3-E1 cells via BMP-2/Smads pathway., PMID:34391912
Specific Blockade of Bone Morphogenetic Protein-2/4 Induces Oligodendrogenesis and Remyelination in Demyelinating Disorders., PMID:34159538
Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p., PMID:34158869
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival., PMID:34013359
Up-regulation of miR-155 potentiates CD34+ CML stem/progenitor cells to escape from the growth-inhibitory effects of TGF-ß1 and BMP signaling., PMID:33907541
Bone morphogenetic protein 7 promotes resistance to immunotherapy., PMID:32973129
Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis., PMID:32746702
Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways via off-VEGF signaling., PMID:32587778
IFNβ signaling inhibits osteogenesis in human SLE bone marrow., PMID:32515653
Disruption of BMP Signaling Prevents Hyperthyroidism-Induced Bone Loss in Male Mice., PMID:32453466
Tumor necrosis factor-related apoptosis-inducing ligand regulate the accumulation of extracelluar matrix in pulmonary artery by activating the phosphorylation of Smad2/3., PMID:32233583
TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?, PMID:32143707
Smad1/5 signal transduction regulates the ameloblastic differentiation of induced pluripotent stem cells., PMID:32022225
Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells., PMID:31586903
Immunofluorescent Visualization of BMP Signaling Activation on Paraffin-Embedded Tissue Sections., PMID:30414134
Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension., PMID:30274147
Erythroferrone inhibits the induction of hepcidin by BMP6., PMID:30097509
Therapeutic antibody directed osteogenic differentiation of induced pluripotent stem cell derived MSCs., PMID:29778895
Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis., PMID:29535220
Urinary IgG4 and Smad1 Are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy., PMID:29490904
MicroRNA-31 is required for astrocyte specification., PMID:29380422
Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP)., PMID:29170109
Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas., PMID:29154973
Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis., PMID:29026072
The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro., PMID:28838258
Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6., PMID:28815688
BMP7 mediates the anticancer effect of honokiol by upregulating p53 in HCT116 cells., PMID:28731124
Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1., PMID:28642261
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5., PMID:28489883
Activation of CD137 Signaling Promotes Angiogenesis in Atherosclerosis via Modulating Endothelial Smad1/5-NFATc1 Pathway., PMID:28288971
Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia., PMID:28202082
Autocrine and paracrine STIP1 signaling promote osteolytic bone metastasis in renal cell carcinoma., PMID:28199984
Combined Effects of Androgen and Growth Hormone on Osteoblast Marker Expression in Mouse C2C12 and MC3T3-E1 Cells Induced by Bone Morphogenetic Protein., PMID:28067796
Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis., PMID:28009989
Follicle-Stimulating Hormone β-Subunit Potentiates Bone Morphogenetic Protein 9-Induced Osteogenic Differentiation in Mouse Embryonic Fibroblasts., PMID:27996168
For research use only. Not for human or drug use.
