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Anti-TPSAB1/Tryptase-1 Polyclonal Antibody

Catalog #:   PHH16101 Specific References (45) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q15661
Overview

Catalog No.

PHH16101

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TPSAB1/Tryptase-1 (Ile31-Pro275).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

TPSB1,TPS2,Tryptase I,Tryptase-1,TPSAB1,Tryptase alpha-1,Tryptase alpha/beta-1,TPS1

Purification

Purified by antigen affinity column.

Accession

Q15661

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with TPSAB1/Tryptase-1 antibody (PHH16101) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 30 kDa
    Observed MW: 30 kDa
References

Hereditary alpha-tryptasemia - a potential cause of severe anaphylactic reactions and a modifier of mast cell diseases., PMID:40450750

Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis., PMID:39828458

Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis., PMID:39524451

Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601

Idiopathic anaphylaxis: Diagnosis and management., PMID:34871155

Adult allergic rhinitis sufferers have unique nasal mucosal and peripheral blood immune gene expression profiles: A case-control study., PMID:34637606

Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia., PMID:33865872

Hereditary alpha-tryptasemia in 101 patients with mast cell activation-related symptomatology including anaphylaxis., PMID:33465452

Clinical response to omalizumab in patients with hereditary α-tryptasemia., PMID:31605754

Hereditary Alpha Tryptasemia: Genotyping and Associated Clinical Features., PMID:30007465

Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells., PMID:29685134

Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen., PMID:22235124

Allergen cleavage by effector cell-derived proteases regulates allergic inflammation., PMID:16585063

The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH., PMID:16493076

Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice., PMID:16359660

Loss of histochemical identity in mast cells lacking carboxypeptidase A., PMID:15988029

Immunohistochemical evaluation of mast cells and mark activity tryptase and chymase in experimental fibrosarcoma., PMID:15638376

Gastric mucosal mast cells are increased in Helicobacter pylori-negative functional dyspepsia., PMID:15017654

An antibody raised against in vitro-derived human mast cells identifies mature mast cells and a population of cells that are Fc epsilon RI(+), tryptase(-), and chymase(-) in a variety of human tissues., PMID:12704212

Mast cells and macrophages in normal C57/BL/6 mice., PMID:12122446

Temporal distribution of distinct mast cell phenotypes during intestinal schistosomiasis in mice., PMID:12060316

Preliminary evaluation of mast cells and angiogenesis processes in experimental fibrosarcoma., PMID:12056643

Preliminary evaluation of mast cells in rats with an experimental fibrosarcoma induced by 3-methylcholanthrene., PMID:11820645

Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease., PMID:11552987

IL-6 attenuates apoptosis, while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells., PMID:11467999

[Other forms of immunomodulation in allergic patients]., PMID:10867378

Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization., PMID:10824103

Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2., PMID:10645907

Detection of tryptase in bovine mast cells: comparison of enzyme- and immuno-histochemistry., PMID:10213671

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis., PMID:9874570

Involvement of alpha-4 integrins in allergic airway responses and mast cell degranulation in vivo., PMID:9769271

Immunolocalization of bFGF in pterygia: association with mast cells., PMID:9294687

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2., PMID:9294103

Molecular basis of proteolytic activation of Sendai virus infection and the defensive compounds for infection., PMID:9165079

[Tryptase: a diagnostic marker in allergic diseases]., PMID:8963645

Mast cells in loosening of totally replaced hips., PMID:8542692

The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis., PMID:8675637

Proteinases of rat mast cells. Peritoneal but not intestinal mucosal mast cells express mast cell proteinase 5 and carboxypeptidase A., PMID:7594601

Expression of the c-kit gene product in normal and neoplastic mast cells but not in neoplastic basophil/mast cell precursors from chronic myelogenous leukaemia., PMID:7490680

Serine proteinases are regionally segregated within mast cell granules., PMID:7837788

Processing of procarboxypeptidase A and other zymogens in murine mast cells., PMID:7929294

Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse., PMID:8077672

Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis., PMID:7929694

Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes., PMID:7510477

Localization of rat tryptase to a subset of the connective tissue type of mast cell., PMID:7685789

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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Distributor list

For research use only. Not for human or drug use.

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Anti-TPSAB1/Tryptase-1 Polyclonal Antibody [PHH16101]
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