Catalog No.
YHN29901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
[Asp2-Leu80] & [Gln142-Gln152]
Predicted molecular weight
38.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92982
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ninjurin-1, Nerve injury-induced protein 1, Secreted ninjurin-1, Soluble ninjurin-1, NINJ1
Cerebral Hemorrhage-Related Inflammatory Response Mediated by NINJ1 and the Protective Effects of Atorvastatin., PMID:40503750
NINJ1 regulates plasma membrane fragility under mechanical strain., PMID:40490006
NINJ1 impairs the anti-inflammatory function of hUC-MSCs with synergistic IFN-γ and TNF-α stimulation., PMID:40467389
Impact of Tobacco Consumption on Salivary Protein Profiles: A MALDI-TOF Mass Spectrometry Study., PMID:40439360
NINJ1 and MMP9: potential biomarkers for intracranial atherosclerosis plaque vulnerability., PMID:40356625
Uncovering NINJ1 in SLE: Biomarker potential for renal and hematologic manifestations., PMID:40334833
NINJ1 exerts a role in the development of preeclampsia through potential regulation by the Notch1 signaling pathway., PMID:40289260
Unraveling the mechanisms of NINJ1-mediated plasma membrane rupture in lytic cell death and related diseases., PMID:40239793
Pyroptosis: molecular mechanisms and roles in disease., PMID:40181184
Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages., PMID:40162563
The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease., PMID:40161842
Development of Novel Peptides That Target the Ninjurin 1 and 2 Pathways to Inhibit Cell Growth and Survival via p53., PMID:40136650
Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation., PMID:40094828
NINJ1 in Cell Death and Ferroptosis: Implications for Tumor Invasion and Metastasis., PMID:40075648
Norovirus co-opts NINJ1 for selective protein secretion., PMID:40020060
Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death., PMID:40010300
NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury., PMID:39979243
Multifaceted roles of ninjurin1 in immunity, cell death, and disease., PMID:39958360
Targeting NINJ1-mediated cell rupture to treat inflammatory diseases., PMID:39953391
Rings of death: How NINJ1 executes plasma membrane rupture., PMID:39855152
The Roles of Ninjurin1 and Estrogen in Modulating AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Male Mice., PMID:39810489
How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot., PMID:39667936
NINJ1: Bridging lytic cell death and inflammation therapy., PMID:39543132
NINJ1 regulates plasma membrane fragility under mechanical tension., PMID:39483869
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture., PMID:39476863
Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis., PMID:39468551
NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation., PMID:39424803
Ninjurin1 deficiency differentially mitigates colorectal cancer induced by azoxymethane and dextran sulfate sodium in male and female mice., PMID:39417611
NINJ1-mediated macrophage plasma membrane rupture and neutrophil extracellular trap formation contribute to oxalate nephropathy., PMID:39380143
NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target., PMID:39197295
NINJ1: A NOVEL SEPSIS SEVERITY AND MORTALITY BIOMARKER., PMID:39193891
Insights into preeclampsia: a bioinformatics approach to deciphering genetic and immune contributions., PMID:39165753
Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture., PMID:39106869
NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4-ANXA2 Interaction and Enhancing Macrophage Infiltration., PMID:38922800
Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture., PMID:38906725
Loss of Ninjurin1 alleviates acetaminophen-induced liver injury via enhancing AMPKα-NRF2 pathway., PMID:38848941
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks., PMID:38614101
Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases., PMID:38479360
NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation., PMID:38464226
Structural and functional insights of NINJ1 in plasma membrane rupture during cell death., PMID:38424287
NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress., PMID:38409108
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis., PMID:38396301
Mechanistic insights from inflammasome structures., PMID:38374299
Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells., PMID:38255907
Development of a TLR-Based Model That Can Predict Prognosis, Tumor Microenvironment, and Drug Response for Esophageal Squamous Cell Carcinoma., PMID:38206423
Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates Wild-Type p53 in Growth Suppression and Mutant p53 in Growth Promotion., PMID:38201656
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death., PMID:38181758
Redox regulation of the NLRP3-mediated inflammation and pyroptosis., PMID:38153050
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression., PMID:38062164
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets., PMID:38030687
For research use only. Not for human or drug use.
