Catalog No.
RHC82423
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P10636
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
CBTAU-22.1
Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse., PMID:40403829
Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease., PMID:40042672
Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease., PMID:39930142
Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease., PMID:39559872
CSF complement proteins are elevated in prodromal to moderate Alzheimer's disease patients and are not altered by the anti-tau antibody semorinemab., PMID:39369294
Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy., PMID:39368113
The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease., PMID:39284839
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death., PMID:39032719
Biomarkers as Endpoints in Clinical Trials for Alzheimer's Disease., PMID:38669547
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies., PMID:38585836
Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features., PMID:38485064
Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation., PMID:38408247
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change., PMID:38353753
Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia., PMID:38198008
Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates., PMID:37408256
Yeast biopanning against site-specific phosphorylations in tau., PMID:37294629
The Effects of a Blood-Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy., PMID:37111315
Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta., PMID:36934970
Altered localization of nucleoporin 98 in primary tauopathies., PMID:36601621
Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper., PMID:36396609
Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation., PMID:36350059
Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy., PMID:36109185
A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model., PMID:35798978
Primary Sjögren's Syndrome Presenting with Rapidly Progressive Dementia: A Case Report., PMID:35761497
Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome., PMID:35676735
Pyramidal cell axon initial segment in Alzheimer´s disease., PMID:35610289
Alzheimer disease neuropathology in a patient previously treated with aducanumab., PMID:35581440
Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?, PMID:35216126
Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation., PMID:34933123
Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction., PMID:34693486
From Cerebrospinal Fluid Neurochemistry to Clinical Diagnosis of Alzheimer's Disease in the Era of Anti-Amyloid Treatments. Report of Four Patients., PMID:34680493
Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in the Era of Disease-Modifying Treatments., PMID:34679323
Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns., PMID:34635189
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia., PMID:34471104
Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies., PMID:34363663
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease., PMID:34129723
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds., PMID:33653397
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model., PMID:33452414
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease., PMID:33380492
A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer's disease., PMID:33075328
Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody., PMID:32894244
Basophilic invasion in the neurohypophysis is increased in patients with Alzheimer's disease., PMID:32589126
The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis., PMID:32536837
Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases., PMID:32106300
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy., PMID:31907603
Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice., PMID:31839610
Glial and neuroaxonal biomarkers in a multiple sclerosis (MS) cohort., PMID:31802051
Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model., PMID:31734318
Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy., PMID:31608704
Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples., PMID:31528297
For research use only. Not for human or drug use.
