Catalog No.
PHG76001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human EBI3/IL27B (Arg21-Lys229).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
IL-27B,Interleukin-27 subunit beta,EBI3,Epstein-Barr virus-induced gene 3 protein,EBV-induced gene 3 protein,IL27B,IL-27 subunit beta
Purification
Purified by antigen affinity column.
Accession
Q14213
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis., PMID:40440970
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway., PMID:40259042
Interleukin-27 Regulates Adaptative Immune Responses Associated With Control of Parasite Replication in Canine Leishmaniasis., PMID:39360782
Levilactobacillus brevis IBARAKI-TS3 Isolated From Pickles Promotes Production of Interleukin-10 via Toll-Like Receptor 2 in Human M2 Macrophages., PMID:39210693
Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis., PMID:38224627
Extensive Survey and Analysis of Factors Associated with Presence of Antibodies to Orthoebolaviruses in Bats from West and Central Africa., PMID:37766333
Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27., PMID:36261006
Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes., PMID:34884474
Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation., PMID:34837777
Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension., PMID:34350241
Mycobacterium tuberculosis (MTB) antigen-induced upregulation of interleukin-35 expression in patients with MTB infection: In vitro blockade of the effects of interleukin-35 on T lymphocyte subsets., PMID:34245560
Decreased interleukin-35 levels and CD4+EBI3+ T cells in patients with type 1 diabetes and the effects of the antibody against CD20 (rituximab)., PMID:33488880
The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†., PMID:33330922
Lack of evidence for expression and function of IL-39 in human immune cells., PMID:33259477
Investigating expression pattern of eight immune-related genes in pemphigus patients compared with the healthy controls and after rituximab therapy: Potential roles of CTLA4 and FCGR3A genes expression in outcomes of rituximab therapy., PMID:33090639
Serum IL-35 Levels Are Associated With Activity and Progression of Sarcoidosis., PMID:32508842
Impact of fascioliasis reinfection on Fasciola hepatica egg shedding: relationship with the immune-regulatory response., PMID:32371223
Blockade of IL-27 signaling ameliorates herpes stromal keratitis with upregulated CD4+ Foxp3+ regulatory T cells influx in mice., PMID:31638041
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis., PMID:31548322
Evidence for IL-35 Expression in Diffuse Large B-Cell Lymphoma and Impact on the Patient's Prognosis., PMID:31316915
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35., PMID:31264967
Increased expression of the immunosuppressive interleukin-35 in patients with non-small cell lung cancer., PMID:30956278
Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice., PMID:30832557
Ebi3 promotes T- and B-cell division and differentiation via STAT3., PMID:30660991
Investigating the potential immune role of IL-35 in grass carp (Ctenopharyngodon idella)., PMID:30590066
Aberrant IL-35 levels in patients with primary Sjogren's syndrome., PMID:30589451
IL-35 interferes with splenic T cells in a clinical and experimental model of acute respiratory distress syndrome., PMID:30584968
Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis., PMID:30513021
Expression of IL33 and IL35 in oral lichen planus., PMID:29633015
Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice., PMID:29138852
Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice., PMID:28989066
Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients., PMID:28738904
Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling., PMID:28280243
Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner., PMID:28042143
Soluble serum VCAM-1, whole blood mRNA expression and treatment response in natalizumab-treated multiple sclerosis., PMID:27919501
Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3., PMID:27682874
Patterns of Immune Regulation in Rhesus Macaque and Human Families., PMID:27500222
Interleukin-27, a novel cytokine induced by ischemia-reperfusion injury in rat hearts, mediates cardioprotective effects via the gp130/STAT3 pathway., PMID:25820907
Immunoregulatory role of IL-35 in T cells of patients with rheumatoid arthritis., PMID:25731770
[IL-35 level of peripheral blood is correlated with the immune response to hepatitis B vaccine]., PMID:25575066
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3., PMID:25348624
Gene expression of subunits of the IL-12 family cytokines in moDCs derived in vitro from the cord blood of children of healthy and allergic mothers., PMID:24785110
Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege., PMID:24760014
First characterization of a teleost Epstein-Barr virus-induced gene 3 (EBI3) reveals a regulatory effect of EBI3 on the innate immune response of peripheral blood leukocytes., PMID:23932982
Overexpression of Epstein-Barr virus-induced gene 3 protein (EBI3) in MRL/lpr mice suppresses their lupus nephritis by activating regulatory T cells., PMID:23845089
The composite cytokine p28/cytokine-like factor 1 sustains B cell proliferation and promotes plasma cell differentiation., PMID:23836062
Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice., PMID:22927332
Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family., PMID:22487722
IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn., PMID:22045869
EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation., PMID:21255010
For research use only. Not for human or drug use.
