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Anti-EDTA chelate of indium (metal chelate) Antibody (CHA255)

Catalog #:   RGN38401 Specific References (49) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: Indium
Overview

Catalog No.

RGN38401

Species reactivity

General

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

EDTA chelate of indium (metal chelate)

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Indium

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

CHA255

Data Image
References

[nat/89Zr][Zr(pypa)]: Thermodynamically Stable and Kinetically Inert Binary Nonadentate Complex for Radiopharmaceutical Applications., PMID:34788042

Preparation and radiolabeling of a lyophilized (kit) formulation of DOTA-rituximab with ⁹⁰Y and ¹¹¹In for domestic radioimmunotherapy and radioscintigraphy of non-Hodgkin's lymphoma., PMID:25074720

Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies., PMID:12236790

CaNa2EDTA for improvement of radioimmunodetection and radioimmunotherapy with 111In and 90Y-DTPA-anti-CEA MAbs in nude mice bearing human colorectal cancer., PMID:10688120

Bis(hydroxamamide)-based bifunctional chelating agent for 99mTc labeling of polypeptides., PMID:9893958

Biological properties of biotin-chelate conjugates for pretargeted diagnosis and therapy with the avidin/biotin system., PMID:9776294

Assessment of radiochemical design of antibodies using an ester bond as the metabolizable linkage: evaluation of maleimidoethyl 3-(tri-n-butylstannyl)hippurate as a radioiodination reagent of antibodies for diagnostic and therapeutic applications., PMID:8950481

Pre-clinical and clinical studies of two new bifunctional chelating agents for immunoscintigraphy with 111In-anti-CEA monoclonal antibody., PMID:8895905

Reassessment of diethylenetriaminepentaacetic acid (DTPA) as a chelating agent for indium-111 labeling of polypeptides using a newly synthesized monoreactive DTPA derivative., PMID:8784442

Antibody responses to macrocycles in lymphoma., PMID:8772643

Stability of a metabolizable ester bond in radioimmunoconjugates., PMID:8868284

Non-covalent antibody-mediated drug delivery., PMID:8078646

A biological method to evaluate bifunctional chelating agents to label antibodies with metallic radionuclides., PMID:8176478

[Comparative studies of 111In-labeled monoclonal antibody using spacer-containing and non-spacer bifunctional chelates: (II). Biodistribution, metabolism and excretion in vivo]., PMID:8028219

[Comparative studies of 111In-labeled monoclonal antibody using spacer-containing and non-spacer bifunctional chelates: (I). Conjugation, labeling, immunoreactivity and in vitro stability]., PMID:8028218

Enzyme immunoassay to determine heavy metals using antibodies to specific metal-EDTA complexes: optimization and validation of an immunoassay for soluble indium., PMID:8203740

How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab'/hapten complexes with different metals in the chelate., PMID:8218161

Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice., PMID:8401377

Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--I. A new reproducible synthetic method., PMID:8401376

A fluorescence quenching method for estimating chelating groups in chelate-conjugated macromolecules., PMID:8456066

A bifunctional HBED-derivative for labeling of antibodies with 67Ga, 111In and 59Fe. Comparative biodistribution with 111In-DPTA and 131I-labeled antibodies in mice bearing antibody internalizing and non-internalizing tumors., PMID:1428911

Localization of infection using streptavidin and biotin: an alternative to nonspecific polyclonal immunoglobulin., PMID:1403148

Copper-64-labeled antibodies for PET imaging., PMID:1517844

Influence of a peptide linker on biodistribution and metabolism of antibody-conjugated benzyl-EDTA. Comparison of enzymatic digestion in vitro and in vivo., PMID:1420442

In vitro stability of EDTA and DTPA immunoconjugates of monoclonal antibody 2G3 labeled with indium-111., PMID:1330982

Structure-function relationships in indium-111 radioimmunoconjugates., PMID:1515465

Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma., PMID:1742739

Purification and characterization of a chimeric bifunctional antibody specific for human carcinoembryonic antigen and indium-benzyl-EDTA., PMID:1821776

Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111., PMID:1917517

New indium-111 labeled biotin derivatives for improved immunotargeting., PMID:1787080

Expression and characterization of a chimeric bifunctional antibody with therapeutic applications., PMID:2116477

Kinetics of the dissociation of indium-(p-substituted-benzyl)ethylenediaminetetraacetic acid hapten analogues from the monoclonal anti-hapten antibody CHA255., PMID:2129016

N,N'-bis(2-hydroxybenzyl)-1-(4-bromoacetamidobenzyl)-1,2 -ethylenediamine-N,N'-diacetic acid: a new bifunctional chelate for radiolabeling antibodies., PMID:2129013

Metabolism of indium chelates attached to monoclonal antibody: minimal transchelation of indium from benzyl-EDTA chelate in vivo., PMID:2107283

An optimized antibody-chelator conjugate for imaging of carcinoembryonic antigen with indium-111., PMID:2341278

Development of a new radiolabel (203Pb) and new chelating agents for labeling monoclonal antibodies for imaging., PMID:1966961

Labeling of monoclonal antibodies with radionuclides., PMID:2503873

Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts., PMID:2785585

Effect of mass of 111In-benzyl-EDTA monoclonal antibody on hepatic uptake and processing in mice., PMID:2493983

Effect of different linkages between chelates and monoclonal antibodies on levels of radioactivity in the liver., PMID:2606714

Synthesis of novel bifunctional chelators and their use in preparing monoclonal antibody conjugates for tumor targeting., PMID:2491892

Monoclonal antibodies as agents for selective radiolabeling of human neutrophils., PMID:3141596

Comparative radiolabeling and distribution of a tumour-directed monoclonal antibody., PMID:3251903

Chelate radiochemistry: cleavable linkers lead to altered levels of radioactivity in the liver., PMID:3162452

Monoclonal antibody modification with chelate-linked high-molecular-weight polymers: major increases in polyvalent cation binding without loss of antigen binding., PMID:3110049

New method for the chelation of indium-111 to monoclonal antibodies: biodistribution and imaging of athymic mice bearing human colon carcinoma xenografts., PMID:3106595

Comparative serum stability of radiochelates for antibody radiopharmaceuticals., PMID:3794813

Improved tumor localization of 111In labeled monoclonal antibody with chelator administration to host nude mice., PMID:3106043

Metal decomposition rates of 111In-DTPA and EDTA conjugates of monoclonal antibodies in vivo., PMID:3106867

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-EDTA chelate of indium (metal chelate) Antibody (CHA255) [RGN38401]
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