Catalog No.
DHJ17802
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a-kappa
Clonality
Monoclonal
Applications
Research Grade Biosimilar
Target
Klotho beta-like protein, KLB, Beta-klotho, BetaKlotho, BKL
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q86Z14
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MK-3655, NGM-313, NGM313
Clone ID
MK-3655
Note
For research use only. Not suitable for clinical or therapeutic use.
Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer., PMID:22355336
Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, phase 1 study., PMID:25087476
Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells., PMID:25170746
Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice., PMID:25790234
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex., PMID:26288846
An efficient route to bispecific antibody production using single-reactor mammalian co-culture., PMID:27680183
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys., PMID:28324011
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies., PMID:28363871
FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases., PMID:28525362
Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening., PMID:28985411
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia., PMID:28988823
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes., PMID:29107292
A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity., PMID:29483191
Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice., PMID:29594879
A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing., PMID:29660397
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions., PMID:30068552
Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod-treated mice., PMID:30302794
Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy., PMID:31462642
The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange., PMID:31581521
Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice., PMID:31800971
Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial., PMID:32034019
Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma., PMID:32431501
Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans., PMID:33139537
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice., PMID:33446655
Results of a Phase 2b Trial With GB001, a Prostaglandin D2 Receptor 2 Antagonist, in Moderate to Severe Eosinophilic Asthma., PMID:35248549
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses., PMID:35263569
A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors., PMID:35655320
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response., PMID:35817532
SARS-CoV-2 Convalescent Sera Binding and Neutralizing Antibody Concentrations Compared with COVID-19 Vaccine Efficacy Estimates against Symptomatic Infection., PMID:35856710
Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine., PMID:36366345
Precision cut intestinal slices, a novel model of acute food allergic reactions., PMID:36377289
The Matrix-M™ adjuvant: A critical component of vaccines for the 21st century., PMID:37113023
Algorithm for optimized mRNA design improves stability and immunogenicity., PMID:37130545
Allergenicity evaluation of quinoa proteins - A study in Brown Norway rats., PMID:37863384
Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab., PMID:38343040
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells., PMID:38418879
Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow's milk allergy., PMID:38448113
Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., PMID:39226764
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice., PMID:39463193
Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells., PMID:39798471
Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials., PMID:39805302
For research use only. Not for human or drug use.
