Catalog No.
YVV31901
Expression system
E. coli
Species
Zika virus (ZIKV)
Protein length
Ser1499-Arg2115
Predicted molecular weight
70.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q32ZE1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Genome polyprotein, Capsid protein C, Capsid protein, Core protein, Protein prM, Precursor membrane protein, Peptide pr, Peptide precursor, Small envelope protein M, Matrix protein, Envelope protein E, Non-structural protein 1, NS1, Non-structural protein 2A, NS2A, Serine protease subunit NS2B, Flavivirin protease NS2B regulatory subunit, Non-structural protein 2B, Serine protease NS3, 3.4.21.91, 3.6.1.15, 3.6.4.13, Flavivirin protease NS3 catalytic subunit, Non-structural protein 3, Non-structural protein 4A, NS4A, Peptide 2k, Non-structural protein 4B, NS4B, RNA-directed RNA polymerase NS5, 2.1.1.56, 2.1.1.57, 2.7.7.48, NS5
Genetic Encoding of Fluorinated Analogues of Phenylalanine for 19F NMR Spectroscopy: Detection of Conformational Heterogeneity in Flaviviral NS2B-NS3 Proteases., PMID:40168619
Reaction Mechanism Path Sampling Based on Parallel Cascade Selection QM/MM Molecular Dynamics Simulation: PaCS-Q., PMID:40152421
The interaction of Orthoflavivirus nonstructural proteins 3 and 5 with human fatty acid synthase., PMID:40131913
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein., PMID:40006954
Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors., PMID:39989958
Dual roles of exostosin glycosyltransferase 1 in Zika virus infection., PMID:39927690
Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches., PMID:39905499
Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic Flaviviridae., PMID:39861795
Antiviral Activity of Ecklonia cava Extracts and Dieckol Against Zika Virus., PMID:39769456
Identification and Evaluation of Natural Compounds as Potential Inhibitors of NS2B-NS3 Zika Virus Protease: A Computational Approach., PMID:39733219
Advances in drug discovery of flavivirus NS2B-NS3pro serine protease inhibitors for the treatment of Dengue, Zika, and West Nile viruses., PMID:39546935
Cellular NONO protein binds to the flavivirus replication complex and promotes positive-strand RNA synthesis., PMID:39499073
In silico validation of allosteric inhibitors targeting Zika virus NS2B-NS3 protease., PMID:39469836
Erp57 facilitates ZIKV-induced DNA damage via NS2B/NS3 complex formation., PMID:39404735
Zika virus NS3 drives the assembly of a viroplasm-like structure., PMID:39345390
Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition., PMID:39274895
Employing Machine Learning-Based QSAR for Targeting Zika Virus NS3 Protease: Molecular Insights and Inhibitor Discovery., PMID:39204173
Cleavage of SQSTM1/p62 by the Zika virus protease NS2B3 prevents autophagic degradation of viral NS3 and NS5 proteins., PMID:39128850
Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations., PMID:39116118
The GA-Hecate Peptide inhibits the ZIKV Replicative Cycle in Different Steps and can Inhibit the Flavivirus NS2B-NS3 Protease after Cell Infection., PMID:39039677
Recent advances in the study of zika virus structure, drug targets, and inhibitors., PMID:39011504
In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection., PMID:39009885
Generalized open-source workflows for atomistic molecular dynamics simulations of viral helicases., PMID:38869150
Identification of novel and potential inhibitors against the dengue virus NS2B/NS3 protease using virtual screening and biomolecular simulations., PMID:38834129
Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease., PMID:38809037
A high-throughput cell-based screening method for Zika virus protease inhibitor discovery., PMID:38796112
Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors., PMID:38746305
The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection., PMID:38673962
How do physicochemical properties contribute to inhibitory activity of promising peptides against Zika Virus NS3 protease?, PMID:38289526
A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease., PMID:38265226
Dual function of Zika virus NS2B-NS3 protease., PMID:38011215
Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression., PMID:37891687
Genetic Encoding of 7-Aza-l-tryptophan: Isoelectronic Substitution of a Single CH-Group in a Protein for a Nitrogen Atom for Site-Selective Isotope Labeling., PMID:37890165
Therapeutic Potential of Antiviral Peptides against the NS2B/NS3 Protease of Zika Virus., PMID:37779969
Repurposing of antiparasitic drugs against the NS2B-NS3 protease of the Zika virus., PMID:37747074
Development in the Inhibition of Dengue Proteases as Drug Targets., PMID:37723635
Mutational analyses, pharmacophore-based inhibitor design and in silico validation for Zika virus NS3-helicase., PMID:37712848
Epigallocatechin Gallate: A Multifaceted Molecule for Neurological Disorders and Neurotropic Viral Infections., PMID:37590965
Identification of Zika virus NS2B-NS3 protease and NS5 polymerase inhibitors by structure-based virtual screening of FDA-approved drugs., PMID:37528667
Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication., PMID:37478852
The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and 19F NMR., PMID:37379675
Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease., PMID:37364769
Zika virus: Critical crosstalk between pathogenesis, cytopathic effects, and macroautophagy., PMID:37334850
Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in "Super-Open" Conformation., PMID:37243192
Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases (Mpro)., PMID:37232419
Investigating the folding dynamics of NS2B protein of Zika virus., PMID:37210794
Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches., PMID:37088408
The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses., PMID:36986663
Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication., PMID:36965673
[Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)]., PMID:36961231
For research use only. Not for human or drug use.
