Catalog No.
PHG66301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTK6 (Phe191-Thr445).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
Protein-tyrosine kinase 6,BRK,PTK6,Breast tumor kinase,Tyrosine-protein kinase BRK
Purification
Purified by antigen affinity column.
Accession
Q13882
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
BRK tyrosine kinase expression in a high proportion of human breast carcinomas., PMID:9266966
Characterization of the 5'-flanking region of the human PTK6 gene., PMID:11997104
Regulated association of protein kinase B/Akt with breast tumor kinase., PMID:15539407
Role of breast tumour kinase in the in vitro differentiation of HaCaT cells., PMID:16086737
Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression., PMID:16179349
Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6., PMID:17997837
Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration., PMID:18077133
STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation., PMID:19393627
PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1., PMID:20554524
PTK6 regulates IGF-1-induced anchorage-independent survival., PMID:20668531
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells., PMID:20687930
Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance., PMID:21603980
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR., PMID:22231447
Effects of simultaneous knockdown of HER2 and PTK6 on malignancy and tumor progression in human breast cancer cells., PMID:23364537
Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis., PMID:34555678
CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice., PMID:37393837
Molecular features and clinical implications of the heterogeneity in Chinese patients with HER2-low breast cancer., PMID:37607916
High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study., PMID:39669579
For research use only. Not for human or drug use.
