InVivoMAb Anti-Human APOE3/4 Antibody (HJ15.6)

Catalog No.

VHB98603

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Apo-E, Apolipoprotein E, APOE

Concentration

1.62 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P02649

Applications

ELISA, FuncS

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

HJ15.6

ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model, Ann Neurol. 2021 Feb 24;89(5):952–966.HJ15.6， doi: 10.1002/ana.26043

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis, hj15.6,Neuron Volume 96, Issue 5, 6 December 2017, Pages 1013-1023.e4

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation,HJ15.6, J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30.

Conformational features of guinea pig apolipoprotein E offer insights into functioning of human apolipoprotein E., PMID:40221014

Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis., PMID:39909173

New insights into innate immunity in Alzheimer's disease: from APOE protective variants to therapies., PMID:39278789

Temporal Characterization of the Amyloidogenic APPswe/PS1dE9;hAPOE4 Mouse Model of Alzheimer's Disease., PMID:38891941

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease., PMID:38824138

The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells., PMID:38806525

Generation of novel anti-apoE monoclonal antibodies that selectively recognize apoE isoforms., PMID:38529702

Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins., PMID:38266643

Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor., PMID:38184821

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread., PMID:38086389

Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population., PMID:38034901

FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice., PMID:37852961

APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation., PMID:37791598

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints., PMID:37749326

Isoform-specific modification of apolipoprotein E by 4-hydroxynonenal: protective role of apolipoprotein E3 against oxidative species., PMID:36661393

Phosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts., PMID:36362449

A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies., PMID:36276649

The envelope protein of Zika virus interacts with apolipoprotein E early in the infectious cycle and this interaction is conserved on the secreted viral particles., PMID:35902969

Does the imbalance in the apolipoprotein E isoforms underlie the pathophysiological process of sporadic Alzheimer's disease?, PMID:35900209

Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer's Disease Patients., PMID:35886870

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia., PMID:35750033

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias., PMID:35298921

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis., PMID:35109920

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol., PMID:34385305

Region-Specific Differences in the Apoe4-dependent Response to Focal Brain Injury., PMID:34376629

Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response., PMID:34190404

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia., PMID:33831349

Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice., PMID:33667684

Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1., PMID:33403386

Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages., PMID:33356389

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases., PMID:33342002

C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease., PMID:33339957

The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population., PMID:32891149

COVID-19-Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches., PMID:32588493

Alzheimer's disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics., PMID:32580638

ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes., PMID:32575521

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner., PMID:32552741

Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants., PMID:32497877

Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells., PMID:32338995

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies., PMID:31564456

Cellular Uptake and Clearance of Oxidatively-modified Apolipoprotein E3 by Cerebral Cortex Endothelial Cells., PMID:31533203

Human apolipoprotein E promotes hepatitis B virus infection and production., PMID:31393946

Intersection of pathological tau and microglia at the synapse., PMID:31277708

Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development., PMID:31213474

Hemocompatibility of amyloid and/or brain targeted liposomes., PMID:30964329

ApoE attenuates unresolvable inflammation by complex formation with activated C1q., PMID:30692699

A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer's disease., PMID:30526652

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism., PMID:30340601

Characterization of apolipoprotein C1 in hepatitis C virus infection and morphogenesis., PMID:30130702

A fast and cost-effective method for apolipoprotein E isotyping as an alternative to APOE genotyping for patient screening and stratification., PMID:29654261

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