Anti-PTCH1 Polyclonal Antibody

Catalog No.

PHG62201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PTCH1 (Glu122-Leu249).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Protein patched homolog 1,PTC1,PTCH,PTCH1,PTC

Purification

Purified by antigen affinity column.

Accession

Q13635

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review., PMID:38928661

A real-world experience of pembrolizumab monotherapy in microsatellite instability-high and/or tumor mutation burden-high metastatic castration-resistant prostate cancer: outcome analysis., PMID:38341460

PTCH1 gene variants rs357564, rs2236405, rs2297086 and rs41313327, mRNA and tissue expression in basal cell carcinoma patients from Western Mexico., PMID:38287479

Autoantibodies to PAX5, PTCH1, and GNA11 as Serological Biomarkers in the Detection of Hepatocellular Carcinoma in Hispanic Americans., PMID:36835134

Computational approaches for discovering significant microRNAs, microRNA-mRNA regulatory pathways, and therapeutic protein targets in endometrial cancer., PMID:36704357

Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer., PMID:35033985

Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS-FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity., PMID:34667115

New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03)., PMID:33405951

Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice., PMID:33291515

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit., PMID:33139559

The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development., PMID:33060130

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration., PMID:32332736

MiR-132/212 promotes the growth of precartilaginous stem cells (PCSCs) by regulating Ihh/PTHrP signaling pathway., PMID:32319512

Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study., PMID:32067683

Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy., PMID:31834207

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism., PMID:31548691

PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change., PMID:31319387

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity., PMID:31263273

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi., PMID:31168089

Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance., PMID:31054872

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells., PMID:30657775

Loss of sonic hedgehog gene leads to muscle development disorder and megaesophagus in mice., PMID:29768039

Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169

A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes., PMID:29515040

Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837

Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear., PMID:29139542

Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype., PMID:28915250

Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328

Basal Cell Carcinoma With Matrical Differentiation: Clinicopathologic, Immunohistochemical, and Molecular Biological Study of 22 Cases., PMID:28368926

Primary cilium alterations and expression changes of Patched1 proteins in niemann-pick type C disease., PMID:28332184

PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation., PMID:27815386

Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part II: Photodynamic Therapy, Vismodegib, Cetuximab, Intralesional Methotrexate, and Radiotherapy., PMID:27436804

Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse., PMID:27164562

Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure., PMID:26979762

Hedgehog Signaling Modulates the Release of Gliotransmitters from Cultured Cerebellar Astrocytes., PMID:26694649

Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix., PMID:26674309

The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis., PMID:26552406

Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667

Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling., PMID:25936505

PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics., PMID:27386018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors., PMID:25263791

Ptch2 mediates the Shh response in Ptch1-/- cells., PMID:25085974

Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling., PMID:24867209

Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor., PMID:24062445

Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source., PMID:23776550

Overexpression of the Hedgehog signalling pathway in head and neck squamous cell carcinoma., PMID:23689223

Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli., PMID:23551431

Detection of disseminated tumor cells in the bone marrow of breast cancer patients using multiplex gene expression measurements identifies new therapeutic targets in patients at high risk for the development of metastatic disease., PMID:23129172

Sonic hedgehog pathway expression in non-small cell lung cancer., PMID:22942905

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