Catalog No.
PHG62201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PTCH1 (Glu122-Leu249).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein patched homolog 1,PTC1,PTCH,PTCH1,PTC
Purification
Purified by antigen affinity column.
Accession
Q13635
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review., PMID:38928661
A real-world experience of pembrolizumab monotherapy in microsatellite instability-high and/or tumor mutation burden-high metastatic castration-resistant prostate cancer: outcome analysis., PMID:38341460
PTCH1 gene variants rs357564, rs2236405, rs2297086 and rs41313327, mRNA and tissue expression in basal cell carcinoma patients from Western Mexico., PMID:38287479
Autoantibodies to PAX5, PTCH1, and GNA11 as Serological Biomarkers in the Detection of Hepatocellular Carcinoma in Hispanic Americans., PMID:36835134
Computational approaches for discovering significant microRNAs, microRNA-mRNA regulatory pathways, and therapeutic protein targets in endometrial cancer., PMID:36704357
Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer., PMID:35033985
Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS-FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity., PMID:34667115
New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause., PMID:33772413
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03)., PMID:33405951
Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice., PMID:33291515
Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit., PMID:33139559
The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development., PMID:33060130
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration., PMID:32332736
MiR-132/212 promotes the growth of precartilaginous stem cells (PCSCs) by regulating Ihh/PTHrP signaling pathway., PMID:32319512
Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study., PMID:32067683
Patched 1-interacting Peptide Represses Fibrosis in Pancreatic Cancer to Augment the Effectiveness of Immunotherapy., PMID:31834207
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism., PMID:31548691
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change., PMID:31319387
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity., PMID:31263273
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi., PMID:31168089
Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance., PMID:31054872
Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells., PMID:30657775
Loss of sonic hedgehog gene leads to muscle development disorder and megaesophagus in mice., PMID:29768039
Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169
A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes., PMID:29515040
Analysis of hedgehog signaling in periocular sebaceous carcinoma., PMID:29423837
Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear., PMID:29139542
Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype., PMID:28915250
Association of expression of the hedgehog signal with Merkel cell polyomavirus infection and prognosis of Merkel cell carcinoma., PMID:28551328
Basal Cell Carcinoma With Matrical Differentiation: Clinicopathologic, Immunohistochemical, and Molecular Biological Study of 22 Cases., PMID:28368926
Primary cilium alterations and expression changes of Patched1 proteins in niemann-pick type C disease., PMID:28332184
PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation., PMID:27815386
Resistance of Nonmelanoma Skin Cancer to Nonsurgical Treatments. Part II: Photodynamic Therapy, Vismodegib, Cetuximab, Intralesional Methotrexate, and Radiotherapy., PMID:27436804
Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse., PMID:27164562
Sonic hedgehog is a chemotactic neural crest cell guide that is perturbed by ethanol exposure., PMID:26979762
Hedgehog Signaling Modulates the Release of Gliotransmitters from Cultured Cerebellar Astrocytes., PMID:26694649
Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix., PMID:26674309
The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis., PMID:26552406
Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina., PMID:26116667
Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling., PMID:25936505
PTCH-1 and MDM2 expression in ameloblastoma from a West African sub-population: implication for chemotherapeutics., PMID:27386018
The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors., PMID:25263791
Ptch2 mediates the Shh response in Ptch1-/- cells., PMID:25085974
Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling., PMID:24867209
Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor., PMID:24062445
Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source., PMID:23776550
Overexpression of the Hedgehog signalling pathway in head and neck squamous cell carcinoma., PMID:23689223
Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli., PMID:23551431
Detection of disseminated tumor cells in the bone marrow of breast cancer patients using multiplex gene expression measurements identifies new therapeutic targets in patients at high risk for the development of metastatic disease., PMID:23129172
Sonic hedgehog pathway expression in non-small cell lung cancer., PMID:22942905