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Anti-HDAC1 Polyclonal Antibody

Catalog #:   PHG58201 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q13547
Overview

Catalog No.

PHG58201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HDAC1 (Val183-Ala482).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Histone deacetylase 1,HDAC1,RPD3L1,HD1

Purification

Purified by antigen affinity column.

Accession

Q13547

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • Western blot
    Various lysates were subjected to SDS PAGE followed by western blot with HDAC1 antibody (PHG58201) at 0.92μg/ml.

    Lane 1: Hela cell lysate
    Lane 2: K562 cell lysate

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 55 kDa
    Observed MW: 62 kDa
  • Immunocytochemistry/ Immunofluorescence
    HDAC1 in Hela Cell Line.
    The Hela cells were fixed with 4% paraformaldehyde (20 min), and then blocked with 5% goat serum for 1h. And the cells were incubated for 2h at 37°C with HDAC1 (PHG58201) at 9.2 μg/ml. The section was then incubated with Goat Anti-Rabbit IgG (Alexa Fluor-594) preabsorbed at 1/100 dilution (Shown in red) for 1 hour at room temperature.Nuclear DNA was labelled with DAPI (shown in blue).
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with HDAC1 antibody (PHG58201) at 1 µg/ml.

    Lane 1: Recombinant Protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 36 kDa
    Observed MW: 36 kDa
References

Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis., PMID:40373963

Genetically encoding ε-N-methacryllysine into proteins in live cells., PMID:40097432

HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells., PMID:39891718

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer., PMID:39888307

Liver oval cells in response to HDAC1 inhibitor trichostatin A: immunohistochemical characterization using OV-6 hepatic expression., PMID:39809587

DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways., PMID:39796711

[The effect of c-Myc on regulating the immune-related ligands in Y subtype small cell lung cancer through histone deacetylase 1]., PMID:39622733

Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma., PMID:39486886

Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors., PMID:39136172

LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2-Induced Lymphangiogenesis., PMID:39119899

ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles., PMID:38956246

Calotropis procera: A double edged sword against glioblastoma, inhibiting glioblastoma cell line growth by targeting histone deacetylases (HDAC) and angiogenesis., PMID:38304784

HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling., PMID:38254102

Expression of acetylated histones H3 and H4 and histone deacetylase enzymes HDAC1, HDAC2 and HDAC6 in simple mammary carcinomas of female dogs., PMID:38028583

Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response., PMID:36934335

A CRISPR/Cas9-mediated screen identifies determinants of early plasma cell differentiation., PMID:36685499

A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production., PMID:36047206

Expression of Protein Acetylation Regulators During Peripheral Nerve Development, Injury, and Regeneration., PMID:35663264

Exploring the mechanism of Qinbaiqingfei-concentrate pills in the treatment of Mycoplasma pneumoniae pneumonia from the perspective of intestinal microbiota and mucosal immunity., PMID:35460847

Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells., PMID:35440172

Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells., PMID:35265209

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression., PMID:34893641

N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer., PMID:34137363

FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling., PMID:33907746

Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112

Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma., PMID:33637599

Histone deacetylase (Rpd3) regulates Drosophila early brain development via regulation of Tailless., PMID:32873153

KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1., PMID:32546700

iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice., PMID:32517688

The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy., PMID:32482755

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis., PMID:31883829

Molecular profiling of radical prostatectomy tissue from patients with no sign of progression identifies ERG as the strongest independent predictor of recurrence., PMID:31741711

Histone deacetylase 1 suppresses Krüppel homolog 1 gene expression and influences juvenile hormone action in Tribolium castaneum., PMID:31439816

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma., PMID:31304633

Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia., PMID:31066008

Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development., PMID:30765517

The Drosophila fussel gene is required for bitter gustatory neuron differentiation acting within an Rpd3 dependent chromatin modifying complex., PMID:30730884

[Primary skin lymphomas: Current therapy]., PMID:30709635

Integrated RNA-seq and ChIP-seq analysis reveals a feed-forward loop regulating H3K9ac and key labor drivers in human placenta., PMID:30642670

Improved early development of porcine cloned embryos by treatment with quisinostat, a potent histone deacetylase inhibitor., PMID:30587665

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress., PMID:30121389

Mass spectrometry and DigiWest technology emphasize protein acetylation profile from Quisinostat-treated HuT78 CTCL cell line., PMID:30012418

Histone deacetylase inhibitor-based chromatin precipitation for identification of targeted genomic loci., PMID:29682593

Chronic sun exposure is associated with distinct histone acetylation changes in human skin., PMID:29150847

HDAC inhibitors enhance the immunotherapy response of melanoma cells., PMID:29137331

A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma., PMID:28892521

Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer., PMID:28870936

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS., PMID:28829415

The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis., PMID:28672879

Identification of zinc finger transcription factor EGR2 as a novel acetylated protein., PMID:28576496

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-HDAC1 Polyclonal Antibody [PHG58201]
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