Anti-ADAM9 Polyclonal Antibody

Catalog No.

PHG53501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ADAM9 (Pro440-Gly680).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Disintegrin and metalloproteinase domain-containing protein 9,Meltrin-gamma,ADAM9,MDC9,MLTNG,ADAM 9,Metalloprotease/disintegrin/cysteine-rich protein 9,Cellular disintegrin-related protein,KIAA0021,MCMP,Myeloma cell metalloproteinase

Purification

Purified by antigen affinity column.

Accession

Q13443

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities., PMID:40427200

An Antibody of the Secreted Isoform of Disintegrin and Metalloprotease 9 (sADAM9) Inhibits Epithelial-Mesenchymal Transition and Migration of Prostate Cancer Cell Lines., PMID:38928352

Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors., PMID:35511740

Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9., PMID:34046406

Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis., PMID:33255937

Tetraspanin CD9 interacts with α-secretase to enhance its oncogenic function in pancreatic cancer., PMID:33042435

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9., PMID:31438640

Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage., PMID:31381863

Licochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathways., PMID:30465574

Fisetin suppresses malignant proliferation in human oral squamous cell carcinoma through inhibition of Met/Src signaling pathways., PMID:29312520

Overexpression of ADAM9 in oral squamous cell carcinoma., PMID:29285199

ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death., PMID:29247567

ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype., PMID:28675123

Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling., PMID:26919242

The Protective Roles of IL-6 Trans-Signaling Regulated by ADAM9 on the Liver in Carbon Tetrachloride-Induced Liver Injury in Mice., PMID:26044069

Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2., PMID:25527158

The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression., PMID:25344581

Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform., PMID:24505114

A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease., PMID:23833070

High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases., PMID:23429442

Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor., PMID:22291012

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development., PMID:21786032

Secretome signature of invasive glioblastoma multiforme., PMID:21574646

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons., PMID:20676056

Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism., PMID:19394555

Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion., PMID:19284887

Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung., PMID:19255780

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells., PMID:19059936

UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines., PMID:19003995

Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines., PMID:18452483

Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration., PMID:17704059

ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin., PMID:16373656

Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pancreatic cancer., PMID:15983444

The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer., PMID:15586220

Increased expression of ADAM family members in human breast cancer and breast cancer cell lines., PMID:15565459

The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins., PMID:15361064

Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis., PMID:15205330

Identification of novel proteins associated with hepatocellular carcinomas using protein microarrays., PMID:14517841

Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs., PMID:12356719

Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes., PMID:11831872

MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin., PMID:11162558

Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom., PMID:10931154

Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility., PMID:10825303

Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney., PMID:10752518

Document Download

Anti-ADAM9 Polyclonal Antibody.pdf