Catalog No.
EMK12001
Expression system
Insect Cells
Species
Mus musculus (Mouse)
Protein length
Met1-Pro673
Predicted molecular weight
80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08642
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-arginine deiminase type-2, 3.5.3.15, Peptidylarginine deiminase II, Protein-arginine deiminase type II, Padi2, Pad2, Pdi, Pdi2
Pad2 deletion induces anxiety‑like behaviors and memory deficits in mice., PMID:40185419
PLC and PAD2 Regulate Extracellular Calcium-Triggered Release of Macrophage Extracellular DNA Traps., PMID:40170382
Citrullination of NF-κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury., PMID:40087815
[The effects and mechanisms of PAD2 inhibitor AFM-30a attenuates pulmonary fibrosis in silicotic mice]., PMID:39909591
Circulating levels of PADs and citrullinated histone H3 in SARS-CoV-2 infection: Influence of genetic polymorphisms., PMID:39904454
Silencing PADI-2 induces antitumor effects by downregulating NF-κB, Nrf2/HO-1 and AKT1 in A549 lung cancer cells., PMID:39700962
Identification of novel PAD2 inhibitors using pharmacophore-based virtual screening, molecular docking, and MD simulation studies., PMID:39543332
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma., PMID:39529192
The vacuolar anti-Pseudomonal activity of neutrophil primary granule peptidyl-arginine deiminase enzymes., PMID:39493757
AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism., PMID:39430255
Citrullination Accompanies the Development of Carotid Atherosclerotic Plaques., PMID:39421992
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages., PMID:39405117
Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism., PMID:39316753
Redundant role of PAD2 and PAD4 in the development of cardiovascular lesions in a mouse model of Kawasaki disease vasculitis., PMID:39250707
Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis., PMID:39215870
Targeting Peptidylarginine Deiminase 3 to Efficiently Suppress Herpes Simplex Virus Type 2 Infection., PMID:39201398
Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765
Peptidylarginine deiminase (PAD): A promising target for chronic diseases treatment., PMID:39127273
Protein Citrullination by Peptidyl Arginine Deiminase/Arginine Deiminase Homologs in Members of the Human Microbiota and Its Recognition by Anti-Citrullinated Protein Antibodies., PMID:38791230
Neutrophil-Derived Peptidyl Arginine Deiminase Activity Contributes to Pulmonary Emphysema by Enhancing Elastin Degradation., PMID:38758115
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis., PMID:38636399
Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation., PMID:38623337
Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease., PMID:38521860
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice., PMID:38401303
Myelin basic proteins charge isomers interact differently with the peptidyl arginine deiminase-2., PMID:38305106
Analysis of the diagnostic and prognostic value of serum PAD2 in patients with sepsis in the intensive care unit., PMID:38281661
Construction of a molecular inflammatory predictive model with histone modification-related genes and identification of CAMK2D as a potential response signature to infliximab in ulcerative colitis., PMID:38274809
PAD2 dysregulation and aberrant protein citrullination feature prominently in reactive astrogliosis and myelin protein aggregation in sporadic ALS., PMID:38253209
Anti-citrullinated α-enolase peptide as a highly sensitive autoantigen in patients with rheumatoid arthritis., PMID:38089987
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps., PMID:38087184
Comparative evaluation of semaphorin-4D, peptidylarginine deiminase-2, and matrix metalloproteinase-8 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis smoker and non-smoker patients before and after non-surgical periodontal therapy., PMID:37846733
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells., PMID:37778380
Co-expression of PADI isoforms during progenitor differentiation enables functional diversity., PMID:37778375
Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients., PMID:37759458
Multiple Sclerosis: New Insights into Molecular Pathogenesis and Novel Platforms for Disease Treatment., PMID:37724675
Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination., PMID:37648716
Peptidylarginine Deiminase Type 2 Predicts Tumor Progression and Poor Prognosis in Patients with Curatively Resected Biliary Tract Cancer., PMID:37627159
Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice., PMID:37326108
Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells., PMID:37310889
Genome-wide identification of RNA modification-related single nucleotide polymorphisms associated with rheumatoid arthritis., PMID:36973646
Identification of super-enhancer-driven peptidyl arginine deiminases as potential biomarkers and therapeutic targets for osimertinib-resistant non-small cell lung cancer., PMID:36479196
Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice., PMID:36224627
Identification of Survival-Related Genes in Acute Myeloid Leukemia (AML) Based on Cytogenetically Normal AML Samples Using Weighted Gene Coexpression Network Analysis., PMID:36212177
Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis., PMID:36076933
Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells., PMID:36010543
Genetic basis of defects in immune tolerance underlying the development of autoimmunity., PMID:35979360
Molecular Mechanism of Protein Arginine Deiminase 2: A Study Involving Multiple Microsecond Long Molecular Dynamics Simulations., PMID:35737372
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism., PMID:35236296
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation., PMID:35218410
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts., PMID:35181688
For research use only. Not for human or drug use.
