Anti-PAK2 Polyclonal Antibody

Catalog No.

PHG43201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PAK2 (Glu177-Ala419).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

S6/H4 kinase,p21-activated kinase 2,p58,PAK-2,PAK2,C-t-PAK2,PAK65,p34,Gamma-PAK,Serine/threonine-protein kinase PAK 2,p27

Purification

Purified by antigen affinity column.

Accession

Q13177

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

4D label-free quantitative proteomic and phosphoproteomic profiling of the kidney in rat models of antimyeloperoxidase-associated vasculitis., PMID:40201969

PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry., PMID:37564209

A study of the mechanisms responsible for the action of new immunosuppressants and their effects on rat small intestinal transplantation., PMID:34785307

Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis., PMID:33465404

Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression., PMID:31852224

Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype., PMID:29213081

Low level Hg2+ exposure modulates the B-cell cytoskeletal phosphoproteome., PMID:29199152

Transcriptome Analysis of Peripheral Blood in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients Identifies TNFR1 and TLR Pathways in the IVIg Response., PMID:27175635

Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study., PMID:25971815

A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women., PMID:24957886

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody., PMID:24620746

Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers., PMID:22886747

Nef surfaces: where to interfere with function., PMID:22103838

p21-activated kinases regulate actin remodeling in glomerular podocytes., PMID:20071462

The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties., PMID:18507705

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF., PMID:16966330

Identification and characterization of HLA-class-I-restricted T-cell epitopes in the putative tumor-associated antigens P21-activated serin kinase 2 (PAK2) and cyclin-dependent kinase inhibitor 1A (CDKN1A)., PMID:16718496

Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1., PMID:16505058

Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction., PMID:16288885

Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases., PMID:15870075

Anti-phosphopeptide antibody, P-STM as a novel tool for detecting mitotic phosphoproteins: identification of lamins A and C as two major targets., PMID:15597429

Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development., PMID:12855553

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin., PMID:12453877

Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin., PMID:12237306

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization., PMID:11782491

Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK., PMID:11121037

Inhibition of CD95/Fas-induced DNA degradation by osmotic cell shrinkage., PMID:11093032

Identification of the Nef-associated kinase as p21-activated kinase 2., PMID:10607567

PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: evidence for the involvement of oxidative stress., PMID:9989786

Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart., PMID:9779826

Heat shock stress induces cleavage and activation of PAK2 in apoptotic cells., PMID:9717744

Proteolytic cleavage and activation of PAK2 during UV irradiation-induced apoptosis in A431 cells., PMID:9712143

Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family., PMID:9693111

The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases., PMID:8798763

Human pancreatic adenocarcinoma-associated antigens defined by novel murine monoclonal antibodies Pak-1 and Pak-2., PMID:2161375

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