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Anti-PAK1 Polyclonal Antibody

Catalog #:   PHG42401 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q13153
Overview

Catalog No.

PHG42401

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PAK1 (Glu252-Cys501).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Alpha-PAK,p65-PAK,PAK-1,Serine/threonine-protein kinase PAK 1,p21-activated kinase 1,PAK1

Purification

Purified by antigen affinity column.

Accession

Q13153

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with PAK1 antibody (PHG42401) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 30 kDa
    Observed MW: 30 kDa
References

Increased Fascin1 and Pak1 Expressions Enhance Age-Associated B-Cell Actin Cytoskeleton Remodeling and Motility., PMID:40500987

JEV NS1' protein enhances cell-to-cell viral spread by inducing the formation of tunneling nanotubes., PMID:40187292

Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis., PMID:39404845

DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress., PMID:39224830

Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses., PMID:38848974

The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability., PMID:38666935

Myeloid-derived grancalcin instigates obesity-induced insulin resistance and metabolic inflammation in male mice., PMID:38167327

A personalized network framework reveals predictive axis of anti-TNF response across diseases., PMID:38118442

PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry., PMID:37564209

Emerging roles of Aurora-A kinase in cancer therapy resistance., PMID:37521867

The multikinase inhibitor axitinib in the treatment of advanced hepatocellular carcinoma: the current clinical applications and the molecular mechanisms., PMID:37325670

Peritoneal autoantibody profiling identifies p53 as an autoantibody target in endometriosis., PMID:36828054

Inhibition effect of PPAR-γ signaling on mast cell-mediated allergic inflammation through down-regulation of PAK1/ NF-κB activation., PMID:35636075

Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro., PMID:34721399

Histomorphological patterns of regional lymph nodes in COVID-19 lungs., PMID:33950285

PAK1-Dependent Antitumor Effect of AAC-11‒Derived Peptides on Sézary Syndrome Malignant CD4+ T Lymphocytes., PMID:33745910

[Histomorphological patterns of regional lymph nodes in COVID-19 lungs]., PMID:33575887

Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ breast cancer., PMID:33474679

The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage., PMID:32785008

Polymeric Vector-Mediated Targeted Delivery of Anti-PAK1 siRNA to Macrophages for Efficient Atherosclerosis Treatment., PMID:33438411

GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells., PMID:30860871

Influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts., PMID:29700602

PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells., PMID:27765920

Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions., PMID:26898755

Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinoma., PMID:26884861

Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1)., PMID:26809475

Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis., PMID:26667168

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2., PMID:26333361

p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma., PMID:25675297

Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover., PMID:25466889

MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer., PMID:25277192

BRAF activates and physically interacts with PAK to regulate cell motility., PMID:25228413

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition., PMID:25074413

Uptake of advanced glycation end products by proximal tubule epithelial cells via macropinocytosis., PMID:23747564

Rac1 selective activation improves retina ganglion cell survival and regeneration., PMID:23734197

Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability., PMID:23653363

P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma., PMID:23535073

Phosphorylation of histone H3 on Ser10 by auto-phosphorylated PAK1 is not essential for chromatin condensation and meiotic progression in porcine oocytes., PMID:23521812

Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma., PMID:23516476

Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer., PMID:23361053

The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1)., PMID:23303955

Inhibition of Leydig tumor growth by farnesoid X receptor activation: the in vitro and in vivo basis for a novel therapeutic strategy., PMID:23124354

Phosphorylation of β-catenin at serine 663 regulates its transcriptional activity., PMID:22369945

Heparin/heparan sulfate/CD44-v3 enhances cell migration in term placenta-derived immortalized human trophoblast cells., PMID:22321833

Laminin-α1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-κB transcription factors but also has adverse effects., PMID:22159078

MUC13 mucin augments pancreatic tumorigenesis., PMID:22027689

Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling., PMID:21748785

Glia maturation factor-γ mediates neutrophil chemotaxis., PMID:21653232

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes., PMID:21371233

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets., PMID:21276423

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-PAK1 Polyclonal Antibody [PHG42401]
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