Catalog No.
PHG42201
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TARDBP (Ser104-Pro262).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
TAR DNA-binding protein 43,TARDBP,TDP-43,TDP43
Purification
Purified by antigen affinity column.
Accession
Q13148
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias., PMID:40318118
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers., PMID:40291716
Investigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model., PMID:39968002
Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers., PMID:39940966
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532
Virus-mediated delivery of single-chain antibody targeting TDP-43 protects against neuropathology, cognitive impairment and motor deficit caused by chronic cerebral hypoperfusion., PMID:39778789
Co-pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases., PMID:39711489
Amygdala-predominant α-synuclein pathology is associated with exacerbated hippocampal neuron loss in Alzheimer's disease., PMID:39659977
Post-mortem neuropathology of idiopathic rapid eye movement sleep behaviour disorder: a case series., PMID:39577924
Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer's disease detection., PMID:39533951
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy., PMID:39400557
Vulnerability of neurofilament-expressing neurons in frontotemporal dementia., PMID:39369804
Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD., PMID:39363348
Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases., PMID:39160362
High-sensitivity in situ capture of endogenous RNA-protein interactions in fixed cells and primary tissues., PMID:39152130
Morphometric analysis of spinal motor neuron degeneration in sporadic amyotrophic lateral sclerosis., PMID:39146882
A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery., PMID:39138578
Production and characterization of novel monoclonal antibodies against pathological human TDP-43 proteins., PMID:38728009
Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43., PMID:38635657
Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1., PMID:38522514
Advancing amyotrophic lateral sclerosis disease diagnosis: A lab-on-chip electrochemical immunosensor for ultra-sensitive TDP-43 protein detection and monitoring in serum patients'., PMID:38490025
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS., PMID:38443601
A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD., PMID:38278991
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia., PMID:38232138
Loss of TDP-43 splicing repression occurs early in the aging population and is associated with Alzheimer's disease neuropathologic changes and cognitive decline., PMID:38133681
Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration., PMID:38111057
Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease., PMID:38093787
Clinicopathologic features of a novel star-shaped transactive response DNA-binding protein 43 (TDP-43) pathology in the oldest old., PMID:38086178
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF., PMID:38025276
Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis., PMID:37793650
Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation., PMID:37748140
Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines., PMID:37586449
Low T-cell reactivity to TDP-43 peptides in ALS., PMID:37545536
Co-administration of Nanowired DL-3-n-Butylphthalide (DL-NBP) Together with Mesenchymal Stem Cells, Monoclonal Antibodies to Alpha Synuclein and TDP-43 (TAR DNA-Binding Protein 43) Enhance Superior Neuroprotection in Parkinson's Disease Following Concussive Head Injury., PMID:37480460
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo., PMID:37434215
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework., PMID:37408314
The identification of high-performing antibodies for TDP-43 for use in Western Blot, immunoprecipitation and immunofluorescence., PMID:37359785
Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia., PMID:37200243
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain., PMID:37118836
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes., PMID:37100087
An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA., PMID:36876945
Raddeanin A Enhances Mitochondrial DNA-cGAS/STING Axis-Mediated Antitumor Immunity by Targeting Transactive Responsive DNA-Binding Protein 43., PMID:36876644
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD., PMID:36809847
Integrated tandem affinity protein purification using the polyhistidine plus extra 4 amino acids (HiP4) tag system., PMID:36807525
A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS., PMID:36789434
Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons., PMID:36769256
Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions., PMID:36592411
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging., PMID:36527486
Tuberous sclerosis complex is associated with a novel human tauopathy., PMID:36469115
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation., PMID:36456471
For research use only. Not for human or drug use.
