Catalog No.
PHG32001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human GRIN2A (Pro23-Ala555).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
N-methyl D-aspartate receptor subtype 2A,NMDAR2A,Glutamate [NMDA] receptor subunit epsilon-1,hNR2A,NR2A,Glutamate receptor ionotropic,NMDA 2A,GRIN2A,GluN2A
Concentration
0.96 mg/ml
Purification
Purified by antigen affinity column.
Accession
Q12879
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus., PMID:39855198
[Significance of immunological markers in patients with obstructive sleep apnea and comorbid pathology]., PMID:39269296
Novel mechanisms of Anshen Dingzhi prescription against PTSD: Inhibiting DCC to modulate synaptic function and inflammatory responses., PMID:38848974
Clinical application of trio-based whole-exome sequencing in idiopathic generalized epilepsy., PMID:36842888
Highly expressed Claudin18.2 as a potential therapeutic target in advanced gastric signet-ring cell carcinoma (SRCC)., PMID:33457012
Immunotherapy in GRIN2A-negative Landau-Kleffner Syndrome., PMID:32441907
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory., PMID:32179753
Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration., PMID:30927362
NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors., PMID:29949761
Understanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets?, PMID:29073350
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation., PMID:28232581
Dysfunction of the blood-cerebrospinal fluid-barrier and N-methyl-D-aspartate glutamate receptor antibodies in dementias., PMID:28176002
Immunity and Inflammation in Epilepsy., PMID:26684336
Integrative neuroscience approach to neuropsychiatric lupus., PMID:26467973
Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons., PMID:26266540
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling., PMID:26027736
Anti-NR2A/B Antibodies and Other Major Molecular Mechanisms in the Pathogenesis of Cognitive Dysfunction in Systemic Lupus Erythematosus., PMID:25955648
Hippocampal receptor complexes paralleling LTP reinforcement in the spatial memory holeboard test in the rat., PMID:25639541
Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease., PMID:25261450
Clustering of surface NMDA receptors is mainly mediated by the C-terminus of GluN2A in cultured rat hippocampal neurons., PMID:25015063
Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model., PMID:24853300
NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities., PMID:24349798
[Melanoma: from molecular studies to the treatment breakthrough]., PMID:24341237
Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease., PMID:24156266
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements., PMID:23760273
Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro., PMID:22486492
Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1, NR2A-D and five novel phosphorylation sites on NR2A and NR2B., PMID:22335236
Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk., PMID:21919190
Antibody-mediated targeted gene transfer of helper virus-free HSV-1 vectors to rat neocortical neurons that contain either NMDA receptor 2B or 2A subunits., PMID:21885042
Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development., PMID:21719075
[Roles and expressions of the NMDA receptor subunits (NR2A and NR2B) in visual cortex area of kittens with the normal visual development and anisometropic amblyopia]., PMID:21604481
Role of endoplasmic reticulum stress in the amygdaloid kindling model of rats., PMID:21604154
NMDA-complexes linked to spatial memory performance in the Barnes maze in CD1 mice., PMID:21377497
A 9-year-old boy in a confused, sleepy state., PMID:19968190
Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus., PMID:19322657
Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors., PMID:15804272
N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat., PMID:12193572
Constitutive expression of heterologous N-methyl-D-aspartate receptor subunits in rat adrenal medulla., PMID:11933047
Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture., PMID:11897109
NMDA receptors and PSD-95 are found in attachment plaques in cerebellar granular layer glomeruli., PMID:11876787
Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular nucleus basalis: effects on in vivo labelling of cholinergic neurons., PMID:11738498
For research use only. Not for human or drug use.
